Pulmonary MicroRNA Expression Profiles Associated with Subchronic Aspergillus fumigatus Exposure. | ||
| Minia Journal of Medical Research | ||
| Volume 31, Issue 2, April 2020, Pages 246-252 PDF (431.4 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.221055 | ||
| Authors | ||
| Laila M. Youssef; Ashraf Khodeary M.; , Eman H. Salama; Alaa A. Abdel-Salam | ||
| Department of Clinical Pathology, Faculty of Medicine- Sohag University. | ||
| Abstract | ||
| Background: Examination of the miRNA profile post-fungal exposure demonstrated a large number of altered miRNAs, study by Denning support previously reported immune responses following A. fumigatus exposure, furthermore, altered miRNAs may serve as potential biomarkers to evaluate fungal exposure. objective: To discuss pulmonary MicroRNA in subchronic Aspergillus fumigates exposure and discuss methods of detection of pulmonary aspergillosis by microRNA. Summary: The genus Aspergillus is extraordinary as exemplified by the diversity of its disease manifestations, almost all termed ―aspergillosis‖, Downregulated miRNAs predicted to target Il13, Il33, and Clec7awere identified, suggesting a possible mechanism that contributes in part to an immune response following subchronic exposures to A. fumigatus.These altered miRNAs may serve as potential biomarkers to evaluate fungal exposure. | ||
| Keywords | ||
| Aspergillus; A.fumigatus; MicroRNAs; Conidiophores; Sabouraud agar | ||
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