Gastroprotective effect of sitagliptin in experimentally-induced peptic ulcer in rats | ||
| Minia Journal of Medical Research | ||
| Volume 31, Issue 2, April 2020, Pages 253-256 PDF (355.92 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.221056 | ||
| Authors | ||
| Remon R. Rofaeil1; Asmaa S. Mohamed2 | ||
| 1Department of Pharmacology, Faculty of Medicine, Minia University, Egypt. | ||
| 2* Department of clinical pharmacy, Faculty of Pharmacy, Deraya University, Minia, Egypt. | ||
| Abstract | ||
| Sitagliptin one of the anti-diabetic drugs. We aimed to evaluate the gastroprotective effect of sitagliptin in indomethacin-induced peptic ulcer in rats. Adult male albino rats were divided to four groups; control, sitagliptin (SIT), indomethacin (IND) and IND+SIT group. In each group, ulcer index, gastric mucosal malondialdehyde (MDA), total nitrites (NOx) and Tumor necrosis factoralpha (TNF-α) were determined. In IND+SIT group, ulcer index, MDA and TNF-α were reduced, as compared to IND group. At the same time, NOx was increased in IND+SIT group, as compared to IND group. In conclusion, sitagliptin showed gastroprotective effect in indomethacin induced peptic ulcer in rats mostly through anti-oxidant and anti-inflammatory actions. | ||
| Keywords | ||
| Sitagliptin; indomethacin; peptic ulcer | ||
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