Association of IL4 gene polymorphism with severity of asthma among Egyptian patients | ||
| Minia Journal of Medical Research | ||
| Volume 31, Issue 2, April 2020, Pages 303-307 PDF (276.02 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.221079 | ||
| Authors | ||
| Noha A. Hussein; Rabab. M Kamal; Christine M. Shawky Hanna | ||
| Department of Bacteriology, El-Minia Faculty of Medicine | ||
| Abstract | ||
| Introduction: Asthma is a chronic inflammatory disorder characterized by airway inflammation caused by many cells and cellular elements. Aim of the work: To find association between IL-4, IL-6 and IL-18 polymorphism and asthma in Egyptian patients. To find the effect of IL-4, IL-6 and IL-18 polymorphism on severity of asthma. Subjects and method: The asthmatic patients participating in this study were from Asthma and Allergy Clinic, Minia chest hospital. Seventy five of asthmatic patients were enrolled in this study. Results: This study was carried on 75 asthmatic patients from Minia chest hospital and 75 healthy controls in the period between May 2017 & January 2018. Future studies should include more patients for more reliable assessment. Considering that bronchial asthma is a complex disease, the hetero-genecity of disease may cause research results to be in consistent. And the statistical power of a small sample associated analysis, there for, there is a need for larger studies to suggest any role of this cytokine gene polymorphism in bronchial asthma and cytokine role in asthma severity. | ||
| Keywords | ||
| Asthma; chronic inflammatory | ||
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