Histological changes in the hippocampus of adult male albino rats following aluminum chloride administration: evidence of aluminum induced neurotoxicity | ||
| Minia Journal of Medical Research | ||
| Article 25, Volume 30, Issue 4, October 2019, Pages 155-157 PDF (563.8 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.221703 | ||
| Authors | ||
| Sahar A. Mokhemer; Entesar A. Saber; Nashwa F. Gamal El-Tahawy; Rehab A. Rifaai; Seham A. Abd El-Aleem | ||
| Department of Histology and Cell Biology, Faculty of Medicine, Minia University | ||
| Abstract | ||
| Background: Aluminum (Al), one of the metals with easily gain access to the nervous system through its presence in a lot of manufactured foods, medicines and drinking water. Aims: This study was designed to demonstrate the effects of Aluminum chloride (Alcl3) administration on rat hippocampus. Materials and Methods: The control group received distilled water orally while the Alcl3 group received 100 mg/kg body weight/day of Alcl3 orally for 42 days. Hippocampi were prepared for histological assessments using hematoxylin and eosin (H&E) stains. Results and Discussion: Alcl3 group showed histopathological changes in rat hippocampus including pyramidal neurons degenerative changes with congestion of the blood capillaries. Conclusion: This study provides strong evidence for the neurotoxic action of Alcl3 on the rat hippocampus. Abbreviations: Aluminum chloride: Alcl3, Aluminum: Al, cornu ammonis: CA. | ||
| Keywords | ||
| Aluminum chloride; neurotoxicity; neurodegeneration; hippocampus | ||
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