Serum biomarkers for the early detection of poly cystic ovary in a sample of non-obese Egyptian women. | ||||
| Minia Journal of Medical Research | ||||
| Article 61, Volume 30, Issue 3, July 2019, Page 298-306 PDF (523.18 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.221964 | ||||
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| Author | ||||
| Attia Mohamed Attia | ||||
| Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. | ||||
| Abstract | ||||
| Background: Polycystic ovary (PCO) is one of the most prevalent endocrinal disturbance among women during their child-bearing period. We aimed to highlight the serum levels of biochemical, endocrinal, and metabolic biomarkers of PCO in non-obese Egyptian women. Methods: This crosssectional study was conducted on 44 non-obese Egyptian women with PCO based on Rotterdam criteria in comparison with 44 healthy control women. The biomarkers levels were detected in the serum using fasting blood samples. Results: There was a significant difference between the two groups regarding the waist circumference and ratio between the waist and hip in the favor of the PCO group (P <0.001). Having the biochemical and endocrinal biomarkers, PCO group showed higher levels of glucose, insulin, triglycerides, cholesterol, low-density lipoprotein, the ratio between luteinizing-hormone and follicle-stimulating-hormone, vascular endothelial growth factor, 17β-estradiol, and testosterone (P <0.001 for all). On the other hand, the PCO showed significant lower levels of progesterone, sex hormone-binding globulin, and high-density lipoprotein (P <0.001 for all). There was no difference between the two groups regarding vitamin D and Kisspeptin (P = 0.095 and 0.944, respectively). Conclusions: Many biomarkers were associated with the risk of PCO development among non-obese women. | ||||
| Keywords | ||||
| Biomarkers; Polycystic ovary; Non-obese women. | ||||
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