Study the mammalian acute toxicity of sodium yttrium fluoride, erbium and ytterbium doped (NaYF4: Er3+, Yb3+) upconversion nanomaterials
Shahba, M., El-Khyat, Z., El-Wassef, M., Sliem, M., Farid, O., El-Tayeb, T. (2022). Study the mammalian acute toxicity of sodium yttrium fluoride, erbium and ytterbium doped (NaYF4: Er3+, Yb3+) upconversion nanomaterials. EKB Journal Management System, 65(8), 699-705. doi: 10.21608/ejchem.2022.121196.5481
Mohamed Shahba; Zakaria El-Khyat; Maha M. El-Wassef; Mahmoud A. Sliem; Omar Farid; Tarek A. El-Tayeb. "Study the mammalian acute toxicity of sodium yttrium fluoride, erbium and ytterbium doped (NaYF4: Er3+, Yb3+) upconversion nanomaterials". EKB Journal Management System, 65, 8, 2022, 699-705. doi: 10.21608/ejchem.2022.121196.5481
Shahba, M., El-Khyat, Z., El-Wassef, M., Sliem, M., Farid, O., El-Tayeb, T. (2022). 'Study the mammalian acute toxicity of sodium yttrium fluoride, erbium and ytterbium doped (NaYF4: Er3+, Yb3+) upconversion nanomaterials', EKB Journal Management System, 65(8), pp. 699-705. doi: 10.21608/ejchem.2022.121196.5481
Shahba, M., El-Khyat, Z., El-Wassef, M., Sliem, M., Farid, O., El-Tayeb, T. Study the mammalian acute toxicity of sodium yttrium fluoride, erbium and ytterbium doped (NaYF4: Er3+, Yb3+) upconversion nanomaterials. EKB Journal Management System, 2022; 65(8): 699-705. doi: 10.21608/ejchem.2022.121196.5481

Study the mammalian acute toxicity of sodium yttrium fluoride, erbium and ytterbium doped (NaYF4: Er3+, Yb3+) upconversion nanomaterials

Egyptian Journal of Chemistry
Article 62, Volume 65, Issue 8, August 2022, Page 699-705  XML PDF (354.48 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.121196.5481
View on SCiNiTO View on SCiNiTO
Authors
Mohamed Shahba email 1; Zakaria El-Khyat2; Maha M. El-Wassef3; Mahmoud A. Sliem4; Omar Faridorcid 5; Tarek A. El-Tayeb6
1Medical Biochemistry, National Research Centre, Cairo, Egypt
2Clinical Biochemistry, National Research Center, Egypt
3Medical Biochemistry Department, National Research Centre, Egypt
4Department of Laser application in photochemistry and photobiology, National Institute of Laser Enhanced Sciences, Cairo University, Egypt.
5Researcher, National organization of drug control and research
6Department of Laser application in photochemistry and photobiology, National Institute of Laser Enhanced Sciences Cairo University, Egypt.
Abstract
The potential toxicity and biocompatibility of sodium yttrium fluoride, erbium and ytterbium doped (NaYF4: Er3+, Yb3+) upconversion nanoparticles are of great importance for their biomedical applications. In this work, the acute toxicity of sodium yttrium fluoride, erbium and ytterbium doped (NaYF4: Er3+, Yb3+) upconversion nanomaterials toxicity was evaluated. Rats received intravenous injection of 10 mg/kg of NaYF4: Er3+, Yb3+ doped upconversion nanoparticles once dose and were observed at two different times (24 hours and 14 days post injection) for acute toxicity compared with control group. The results of hematological, blood biochemical analyses indicated that NaYF4: Er3+, Yb3+ doped upconversion nanoparticles treated rats survived for 14 days without any evident of toxic effects. Histopathological analysis of major organs including liver had no obvious signs of abnormality after intravenous injection of rats by NaYF4: Er3+, Yb3+ doped upconversion nanoparticles.
Keywords
NaYF4: Er3+; Yb3+ doped upconversion nanoparticles & acute toxicity
Statistics
Article View: 501
PDF Download: 250