Is There a Correlation Between Pulmonary Inflammation Index With COVID-19 Disease Severity and Outcome? | ||
| SVU-International Journal of Medical Sciences | ||
| Article 6, Volume 5, Issue 2, July 2022, Pages 35-50 PDF (493.52 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2022.119822.1271 | ||
| Authors | ||
| Islam Galal* 1; Aliae AR Mohamed Hussein2; Mohammed M. Mohammed3; Howaida K. Abd ElAal4; Karim Aly5; Islam ElNakeeb6; Ahmed Hamdy Ahmed Mhsb7; Mohamed M. Amin8 | ||
| 1Chest Department, Aswan University Hospitals, Aswan, Egypt. | ||
| 2Chest Department, Assiut University Hospitals, Assiut,71515, Egypt. | ||
| 3Public Health Department, Cairo University, Cairo, Egypt. | ||
| 4Internal Medicine and Surgery (adults) Department, Faculty of Nursing, Assiut University, Assiut,71515, Egypt. | ||
| 5Cardiology Department, Assiut University Hospitals , Assiut,71515, Egypt. | ||
| 6Clinical Pathology Department, Aswan University Hospitals, Aswan, Egypt. | ||
| 7Diagnostic Radiology Department, Aswan University Hospitals, Aswan, Egypt. | ||
| 8Microbiology and Immunology Department,Faculty of ,Medicine, Aswan University, Aswan, Egypt. | ||
| Abstract | ||
| Background: The radiologic pulmonary inflammatory index (PII) may be used as an early predictor of inflammation as laboratory assessments in COVID-19 cases. The purpose of this study was tocompare the clinical and radiological features between cases of COVID-19 necessitating admittance to the intensive care unit (ICU) and those who did not, and to correlate the PII with other inflammatory markers and outcomes. Patients and methods: 72 patients consecutively admitted with confirmed COVID-19. Their electronic records were retrospectively revised and the demographic, clinical, laboratory (complete blood count, C- reactive protein, D dimer, and serum ferritin), High resolution computed tomography (HRCT) data, PII, and the outcomes of the patients were analyzed. Results: They were 50/50%, males/females, with mean age 47.1 ± 16.8 years. During their stay, 15.3% necessitated ICU admittance, 68% cured and discharged, 9 cases referred and 6.9% died. The baseline lesions identified were ground-glass opacification recognized in (93%), higher PII and >3 lobes affection was considerably recorded in those who required ICU admittance (P= 0.041 and 0.013). There was a mild positive correlation between PII with age (r=0.264, P=0.031) and other prognostic inflammatory indicators as ferritin (r=0.225, P=0.048), D Dimer (r=0.271, P=0.043), and serum creatinine. Conclusions: The use of PII together with clinical and laboratory data may be valuable in defining the inflammatory state of COVID-19. This may allow clinicians to avoid the progression of the illness and improve the cure rates by proper early intervention. | ||
| Keywords | ||
| COVID-19; coronavirus disease; SARS-CoV-2; Chest HRCT; Pulmonary inflammation index; Ferritin; CRP; severity; ICU; outcomes | ||
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