Omega-3 Ameliorates Effects of Letrozole-Induced Polycystic Ovary Syndrome in Adult Female Rats | ||||
| Minia Journal of Medical Research | ||||
| Volume 30, Issue 1, March 2019, Page 12-26 PDF (790.29 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.222762 | ||||
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| Authors | ||||
| Selim M. Abdel Hakim; Adel H. Saad | ||||
| Physiology department, Faculty of Medicine, Minia University | ||||
| Abstract | ||||
| Background and aim: Polycystic ovary syndrome (PSOS) is a common disease of multifactorial etiology causing dangerous complications for women. The pathophysiology and intrinsic mechanisms underlying PCOS are complex and not fully determined. This study is designed to explore the mechanisms involved in PCOS in rats and to investigate the possible role of omega-3 in prevention of PCOS. Methods: 24 adult female albino rats were randomly classified into (1) Control groups (C): either non-treated (5 rats) or treated with the vehicle (3 rats), (2) Letrozole group (L): (8 rats), rats received letrozole orally (1mg/kg for 21 days) to induce PCOS and (3) Letrozole and omega-3 group (LO): (8 rats), in which PCOS was induced by letrozole and rats simultaneously received omega-3 (240 mg/kg orally) for 3 weeks. Histopathological examination of ovaries and biochemical analysis for serum was done. Results: In L group, ovaries showed features of polycystic ovary syndrome. The body weight, lipid peroxides, serum levels of insulin, testosterone, TNF-glucose, TGs, TC, and LDL were significantly increased associated with a significant decrease in serum HDL and FSH. In LO group the body weight, lipid peroxides and serum levels of insulin, testosterone, TNF-α, glucose, TGs, TC and LDL were significantly decreased associated with a significant increase in serum HDL. Microscopic examination of the ovaries revealed that LO group showed improvement of polycystic features. Conclusion: Administration of omega-3 led to improvement of PCOS as regard to the histopathological and biochemical changes most probably via its anti-oxidant and anti-inflammatory effects. | ||||
| Keywords | ||||
| Polycystic ovary; Omega-3; Oxidative stress; Anti-oxidant | ||||
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