Role of T- regulatory cells and FOXP3 in lupus nephritis | ||
| Minia Journal of Medical Research | ||
| Volume 30, Issue 1, March 2019, Pages 87-89 PDF (113.12 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.222782 | ||
| Authors | ||
| Amal K. Helmmy1; , Ahmed A. Saedii2; Eman G. Goma2 | ||
| 1Department of Internal Medicine, Faculty of medicine – Minia University | ||
| 2Department of Clinical Pathology, Faculty of medicine – Minia University | ||
| Abstract | ||
| Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a progressive breakdown of tolerance to self-antigens and the presence of concomitant hyperactive immune responses (Giang and La Cava, 2016). Aim of the work: The aim of this study is to assess the level of CD4, CD25 and FOXP3 T-regulatory cells in lupus nephritis patients in regard to disease activity. Subjects and Methods: The present study was conducted out on 100 subjects from the attendants of the outpatient clinics of internal medicine department, Minia university hospital, during the period from April 2016 to June 2017, 70 patients were diagnosed as lupus nephritis according to the presence of proteinuria (>500mg/24h) and/or hematuria and/or urinary casts, according to the recent recommendations from European League Against Rheumatism and 30 apparently healthy subjects as control matched for age and sex (Bertsias GK et al., 2012). Results: This study was carried out on 100 subjects classified into two groups: Group 1: Included 70 patients diagnosed as lupus nephritis 15 males and 55 females, their ages range from (22-40) years. Group 2: Included 30 apparently healthy subjects, 7 males and 23 females their ages from (20-40) years. Discussion: Lupus nephritis (LN) is mainly used to define the immune complex-mediated glomerulonephritis (GN) and it is the most important complication of systemic lupus erythematosus (SLE), which is responsible for SLE related mortality and morbidity. LN occurs in up to 50% of patients with SLE. In LN, the deposition of immune complexes plays a leading role in the initiation of the disease (Shakweer et al., 2016). Conclusion: Tregs % was found significantly lower in active lupus nephritis especially stage (III and IV) and correlates with all parameters of disease activity. Limitations: Limitations to be considered in the present study including the small number of patients, which does not allow for definite conclusions, and the lack of functional assays for more precise Tregs characterization. Furthermore, it would be helpful to assess the urinary levels of Foxp3 mRNA, in parallel to serum levels, in order to clarify their importance in LN activity and response to treatment. | ||
| Keywords | ||
| AC9:Adenylyl cyclase 9; APCs: Antigen-presenting cells; IgM: Immunoglobulin M | ||
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