Role of Leptin as A Risk Factor and Prognostic Marker in Patients with Acute Coronary Syndrome | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 55, Volume 87, Issue 1, April 2022, Pages 1322-1327 PDF (477.55 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2022.223603 | ||
| Authors | ||
| Sameh Attia; Bandar Abdulla; Khaled Saeed | ||
| Abstract | ||
| Background: Leptin is a bioactive substance secreted by adipose tissue and exerts pleiotropic actions on glucose metabolism. It may promote atherosclerosis and increase cardiovascular events. Objective: The aim of this study was to determine the role of leptin as a risk factor in non-obese patients presented with acute coronary syndrome and its relation to midterm prognosis. Patients and Methods: The study included 60 non-obese patients who were presented to Coronary Care Unit (CCU) of Ain Shams University Hospital with acute coronary syndrome (ACS). Patients were classified into 3 Groups. Group A was composed of 30 patients presented with ST-segment elevation myocardial infarction (STEMI), Group B included 15 patients presented with non-ST segment elevation myocardial infarction (NSTEMI) and Group C included 15 patients presented with unstable angina. The study also included control group composed of 20 healthy non-obese subjects who gave no history of chest pain or symptoms suggestive of coronary artery disease (CAD). Results: Mean serum leptin level in all patients was significantly higher compared to control group. As regards complications; mean serum leptin level was higher in patients with adverse outcome compared to other patients. Conclusion: The concentration of leptin is positively correlated with ACS. The mean value of serum leptin in all patients was significantly higher compared to control. The study suggests that leptin is a significant cardiovascular risk factor for ACS independent of traditional cardiovascular risk factors. Serum leptin may be a useful marker in risk stratification of ACS. | ||
| Keywords | ||
| Acute coronary syndrome; Adipocytokines; Atherosclerosis; Leptin | ||
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