HYPOURICEMIC EFFECT OF ANTIDESMA BUNIUS (L.) LEAVES EXTRACT AND IDENTIFICATION OF FLAVONOID CONTENT | ||||
| Al-Azhar Journal of Pharmaceutical Sciences | ||||
| Article 1, Volume 65, Issue 1, March and April 2022, Page 1-15 PDF (1.51 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajps.2022.223765 | ||||
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| Author | ||||
| Dina Elnaggar* | ||||
| Dapartment of Pharmacognosy, Faculty of Pharmacy Egyptian Russian University, Badr City, Cairo, Egypt. | ||||
| Abstract | ||||
| Phytochemical investigation of Antidesma bunius (L.) sprengleaf ethyl acetate extract led to the isolation and identification of amentoflavone 7-O-β-D-glucoside, kaempferol 3-O-β-D-glucoside (Astragalin) and quercetin 7-O-α-L-rhamnopyranosyl-(1′′′→6′′ )-O-β-D-glucopyranoside (Quercetin-7-O-rutinoside) isolated for the first time from A. bunius leaf together with amentoflavone which is previously reported in A.bunius leaf. Detailed phenolics profile in A. bunius leaves ethyl acetate extract using HPLC-DAD-ESI- MS / MS analysis revealed a total of 12 metabolites belonging to flavonoids and phenolic acids. Xanthine oxidase inhibition and hypouricemic effect in vitro bioassays recommends for the potential use of A. bunius leaf extract for the treatment of gout. | ||||
| Keywords | ||||
| Antidesma bunius; biflavone glycoside; flavonoids; xanthine oxidase; hypouricemic | ||||
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