Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties
Snoussi, M., Ghabi, A., abid, M., Althunayyan, A., Alassaf, A., Alminderej, F., E. A. E. Albadria, A., El-Sayed, W., Kadri, A., Aouadi, K. (2023). Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties. EKB Journal Management System, 66(1), 353-360. doi: 10.21608/ejchem.2022.126231.5597
Mejdi Snoussi; Ameni Ghabi; Magdy El-Sadek abid; Abdullah Althunayyan; Azda Alassaf; Fahad Alminderej; Abuzar E. A. E. Albadria; Wael A. El-Sayed; Adel Kadri; Kais Aouadi. "Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties". EKB Journal Management System, 66, 1, 2023, 353-360. doi: 10.21608/ejchem.2022.126231.5597
Snoussi, M., Ghabi, A., abid, M., Althunayyan, A., Alassaf, A., Alminderej, F., E. A. E. Albadria, A., El-Sayed, W., Kadri, A., Aouadi, K. (2023). 'Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties', EKB Journal Management System, 66(1), pp. 353-360. doi: 10.21608/ejchem.2022.126231.5597
Snoussi, M., Ghabi, A., abid, M., Althunayyan, A., Alassaf, A., Alminderej, F., E. A. E. Albadria, A., El-Sayed, W., Kadri, A., Aouadi, K. Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties. EKB Journal Management System, 2023; 66(1): 353-360. doi: 10.21608/ejchem.2022.126231.5597

Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties

Egyptian Journal of Chemistry
Volume 66, Issue 1, January 2023, Pages 353-360    PDF (878.73 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.126231.5597
Authors
Mejdi Snoussi1; Ameni Ghabi2; Magdy El-Sadek abid3; Abdullah Althunayyan4; Azda Alassaf5; Fahad Alminderej5; Abuzar E. A. E. Albadria5; Wael A. El-Sayed6, 7; Adel Kadri8; Kais Aouadi* 9
1University of Hail, KSA
2University of Monastir
3Chemistry Department, College of Sciences & Art, . Jouf University, Saudi Arabia
4Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia
5Department of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi Arabia
6Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia.
7Photochemistry Department, National Research Centre, Dokki, Cairo 12622, Egypt
8Faculty of Science of Sfax, Department of Chemistry, University of Sfax, B.P. 1171, 3000 Sfax, Tunisia.
9Department of Chemistry, College of Science, Qassim University, buraidah
Abstract
Some novel enantiopure 3-carboxylic isoxazolidine derivatives were synthesized by stereocontrol 1,3-dipolar cycloaddition (1,3-DC) between nitrone derived (-)-menthone with alkenes derived from phenol and benzyl alcohol. Furthermore, the synthesized molecules were optimized for their drug-likeness and pharmacokinetics parameters by using in silico methods.
Keywords
isoxazolidines; enantiopure; chiral nitrone; drug-likeness; pharmacokinetics
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