Cardioprotective Effects of Nano-Vitamin D on Isoprenaline-Induced Myocardial Infarction Rat Model

Galal, Omyma; Mostafa, Ahmed; Mohamed, Haytham; Ahmed, Ahmed R.H.; Hashim, Marwa S.; Mohamed, Nagwa

doi:10.21608/svuijm.2022.131434.1301

	Cardioprotective Effects of Nano-Vitamin D on Isoprenaline-Induced Myocardial Infarction Rat Model
SVU-International Journal of Medical Sciences
Article 14, Volume 5, Issue 2, July 2022, Page 136-151 PDF (327.84 K)
Document Type: Original research articles
DOI: 10.21608/svuijm.2022.131434.1301
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Authors
Omyma Galal¹; Ahmed Mostafa²; Haytham Mohamed³; Ahmed R.H. Ahmed ⁴; Marwa S. Hashim⁵; Nagwa Mohamed ²
¹Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt.
²Department of Medical Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt
³Department of Medical Physiology, Faculty of Medicine, South Valley University, Qena, Egypt
⁴Department of Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt
⁵Department of Biochemistry, Faculty of Medicine, Sohag University, Sohag, Egypt.
Abstract
Background: Cardiovascular disease (CVD) is a public health problem accounting for 17.9 million deaths worldwide in 2019. Vitamin D is a fat-soluble vitamin that has various cardioprotective actions and its deficiency is associated with a variety of CVDs. Nano systems for vitamin D may overcome the variable oral bioavailability, poor water solubility and chemical degradation of vitamin D. Objectives: The potential cardioprotective effect of oral vitamin D and vitamin D nanoparticles was evaluated on isoprenaline induced myocardial infarction (MI) rat model. Materials and method: the study evaluated the effect of vitamin D and vitamin D nanoparticles on MI rate models. MI induced by isoprenaline 100 mg/ kg on the last two days of the 30 day treatment period. We analyzed cardiac injury, lipid peroxidation markers and lipid profile. Results: isoprenaline treated rats show marked elevation in cardiac troponin-I (cTn-I), and malondialdehyde (MDA), (p value <0.0001). Oral vitamin D reduced cTn-I and MDA levels and improved lipid profile. Vitamin D nanoparticles enhance the cardioprotective effect of conventional vitamin D. Conclusion: vitamin D nanoparticles have a more efficient cardioprotective effect against isoprenaline induced MI in rats compared to oral conventional vitamin D.
Keywords
myocardial infarction; isoprenaline; vitamin D; vitamin D nanoparticles


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