Cardioprotective Effects of Nano-Vitamin D on Isoprenaline-Induced Myocardial Infarction Rat Model | ||
| SVU-International Journal of Medical Sciences | ||
| Article 14, Volume 5, Issue 2, July 2022, Pages 136-151 PDF (327.84 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2022.131434.1301 | ||
| Authors | ||
| Omyma Galal1; Ahmed Mostafa2; Haytham Mohamed3; Ahmed R.H. Ahmed4; Marwa S. Hashim5; Nagwa Mohamed* 2 | ||
| 1Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||
| 2Department of Medical Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt | ||
| 3Department of Medical Physiology, Faculty of Medicine, South Valley University, Qena, Egypt | ||
| 4Department of Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt | ||
| 5Department of Biochemistry, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||
| Abstract | ||
| Background: Cardiovascular disease (CVD) is a public health problem accounting for 17.9 million deaths worldwide in 2019. Vitamin D is a fat-soluble vitamin that has various cardioprotective actions and its deficiency is associated with a variety of CVDs. Nano systems for vitamin D may overcome the variable oral bioavailability, poor water solubility and chemical degradation of vitamin D. Objectives: The potential cardioprotective effect of oral vitamin D and vitamin D nanoparticles was evaluated on isoprenaline induced myocardial infarction (MI) rat model. Materials and method: the study evaluated the effect of vitamin D and vitamin D nanoparticles on MI rate models. MI induced by isoprenaline 100 mg/ kg on the last two days of the 30 day treatment period. We analyzed cardiac injury, lipid peroxidation markers and lipid profile. Results: isoprenaline treated rats show marked elevation in cardiac troponin-I (cTn-I), and malondialdehyde (MDA), (p value <0.0001). Oral vitamin D reduced cTn-I and MDA levels and improved lipid profile. Vitamin D nanoparticles enhance the cardioprotective effect of conventional vitamin D. Conclusion: vitamin D nanoparticles have a more efficient cardioprotective effect against isoprenaline induced MI in rats compared to oral conventional vitamin D. | ||
| Keywords | ||
| myocardial infarction; isoprenaline; vitamin D; vitamin D nanoparticles | ||
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