Heterocyclization of Thiourea Derivative to Novel Azines and Azoles: Antioxidant and Antimicrobial studies | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 1, January 2023, Pages 169-174 PDF (481.45 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2022.132131.5814 | ||
| Authors | ||
| Mohamed Abd El-Azim1; mohammed gomma assy2; Wael Farid3; atef abdelhamid* 4 | ||
| 1Department of Chemistry, Faculty of Science, Zagazig University, Egypt. | ||
| 2Department of Chemistry, Faculty of Science, Zagazig University, (Egypt) | ||
| 3Department of chemistry, faculty of science, Zagazig university | ||
| 4Department of chemistry, faculty of science, Zagazig university, Egypt | ||
| Abstract | ||
| N,N'-disubstituted thiourea derivative 2 underwent oxidative cyclization with Br2/AcOH mixture to give thiazole 3.Thiadiazole 6 was obtained as the result of chlorination of 2 followed by amination and subsequent intramolecular cyclodehydraration. Thermal treatment of N,N'-disubstituted thiourea derivative 2 with TEA in DMF resulted in hydrolysis of 2 to furnish thiourea derivative 8. Treatment of compound 8 with semicarbazide, thiosemicarbazide, diethyl succinate, diethyl malonate / benzaldehyde or urea resulted in the formation of triazoles 11a,b, pyrrole 13, thiazine 16 and oxathiazole 19. The newly synthesized compounds were tested for their antioxidant and antimicrobial activities. | ||
| Keywords | ||
| Thiazole; Triazole; Thiadiazole; Oxathiazole; Anti-oxidant | ||
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