Value of Urinary Ceruloplasmin as a Marker in Juvenile SLE | ||
| The Egyptian Journal of Pediatric Allergy and Immunology | ||
| Article 2, Volume 20, Issue 1, April 2022, Pages 3-6 PDF (529.87 K) | ||
| Document Type: Review | ||
| DOI: 10.21608/ejpa.2022.231501 | ||
| Authors | ||
| Elham Hossny* 1; Mohammad Sharaf2; Nancy Wahba3; Abdulrahman Warsame4 | ||
| 1Pediatric Allergy, Immunology and Rheumatology Unit, Children’s Hospital, Ain Shams University; | ||
| 2Pediatric Nephrology Unit, Children’s Hospital, Ain Shams University; | ||
| 3Department of Clinical Pathology, Ain Shams University | ||
| 4Public Health Hospital, Benadir, Somalia | ||
| Abstract | ||
| Abstract There is substantial evidence that lupus nephritis (LN) is primarily related to type-III hypersensitivity reactions leading to immune complex deposition at the mesangial, subendothelial, and/or subepithelial space near the renal glomerular basement membrane. The search for a non-invasive urinary marker of lupus nephritis is an appealing point of research. There are few studies that have evaluated the role of urinary ceruloplasmin (CP) as a biomarker for LN. Being expressed at high levels by parietal epithelial cells of Bowman’s capsule it could possibly detoxify molecules as they pass through the glomerular filter. CP is a highly effective antioxidant that can prevent oxidative damage to lipids, DNA, and proteins. However, it is unlikely that a single biomarker can replace clinical parameters to monitor disease progression and detect early renal flares. | ||
| Keywords | ||
| Juvenile SLE; urinary ceruloplasmin | ||
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