Interleukin 17 role as a biomarker in Systemic Lupus Erythematosus patients. | ||
| Sohag Medical Journal | ||
| Article 7, Volume 26, Issue 1, January 2022, Pages 42-50 PDF (746.06 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/smj.2022.131003.1313 | ||
| Authors | ||
| Asmaa Tarazan Mostafa* 1; Amany Abbass Abd Allah2; Sahar Abo alfotoh Abd Alwahed3; Rania Hafez4; Safenaz Hussien5; Rania Mohamed Bakry6 | ||
| 1Assistant Lecturer of Clinical and Chemical Pathology-Faculty of medicine- Sohag University. | ||
| 2Lecturer of Clinical and Chemical Pathology-Faculty of medicine-Sohag University. | ||
| 3Assistant Professor of Clinical and Chemical Pathology-Faculty of medicine-Sohag University. | ||
| 4Associate Professor of Clinical hematology and bone marrow transplant -Internal medicine department -faculty of medicine-Assiut University. | ||
| 5Assistant Professor of Clinical hematology and bone marrow transplant -Internal medicine department -Faculty of medicine-Assiut University. | ||
| 6Professor of Clinical Pathology-South Egypt Cancer Institute-Assiut University. | ||
| Abstract | ||
| Abstract: Objective: The purpose of this study is to determine the interleukin 17 (IL-17) level in cases with Systemic lupus erythematosus (SLE), in addition to assessing the correlation of IL-17 with the activity of the disease. Patients and Methods: The present research recruited 60 adult SLE cases versus 60 healthy subjects serving as controls. Subjects had a full clinical evaluation, history taking as well as evaluation of disease activity in cases with SLE via the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). The serum level of IL-17 was measured in controls as well as SLE patients. Results: The IL-17 levels were substantially elevated in the SLE cohort than in controls. In addition, its level was positively related to SLEDAI. Conclusion: The present study findings revealed maximized IL-17 levels in SLE cases, denoting their contribution to the activity as well as the pathogenesis of the disease. Serum IL-17 levels were significantly positively related to the activity of the disease, 24 h protein in the urine, and anti-dsDNA. | ||
| Keywords | ||
| Systemic lupus erythematosus; Interleukin-17; Disease Activity | ||
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