A review on Synthesis and Biological Evaluations of Pyrazolo[3,4-d]pyrimidine Schaffold
Salem, I., Mostafa, S., El Sabbagh, O., Salama, I., Ibrahim, T. (2022). A review on Synthesis and Biological Evaluations of Pyrazolo[3,4-d]pyrimidine Schaffold. EKB Journal Management System, 6(1), 28-50. doi: 10.21608/rpbs.2022.126019.1129
Ibrahim Mostafa Salem; Samia M Mostafa; Osama Ibrahim El Sabbagh; Ismail Salama; Tarek Salah Ibrahim. "A review on Synthesis and Biological Evaluations of Pyrazolo[3,4-d]pyrimidine Schaffold". EKB Journal Management System, 6, 1, 2022, 28-50. doi: 10.21608/rpbs.2022.126019.1129
Salem, I., Mostafa, S., El Sabbagh, O., Salama, I., Ibrahim, T. (2022). 'A review on Synthesis and Biological Evaluations of Pyrazolo[3,4-d]pyrimidine Schaffold', EKB Journal Management System, 6(1), pp. 28-50. doi: 10.21608/rpbs.2022.126019.1129
Salem, I., Mostafa, S., El Sabbagh, O., Salama, I., Ibrahim, T. A review on Synthesis and Biological Evaluations of Pyrazolo[3,4-d]pyrimidine Schaffold. EKB Journal Management System, 2022; 6(1): 28-50. doi: 10.21608/rpbs.2022.126019.1129

A review on Synthesis and Biological Evaluations of Pyrazolo[3,4-d]pyrimidine Schaffold

Records of Pharmaceutical and Biomedical Sciences
Article 3, Volume 6, Issue 1, April 2022, Page 28-50  XML PDF (1.46 MB)
Document Type: Original Article
DOI: 10.21608/rpbs.2022.126019.1129
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Authors
Ibrahim Mostafa Salem1; Samia M Mostafa email 2; Osama Ibrahim El Sabbagh3; Ismail Salama4; Tarek Salah Ibrahim5
1Zagazig elsharkia governement Hehia elsharkia governement
2Medicinal Chemistry Department, Suez Canal University, Faculty of Pharmacy, Ismailia, Egypt
3Medicinal Chemistry Departement, Faculty of Pharmacy, Zagazig University
4Faculty of Pharmacy - Suez Canal University
5Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University
Abstract
Pyrazolo[3,4-d]pyrimidine is a bicyclic hetero organic nucleus that encompass a pyrazole ring fusion with a pyrimidine ring. It was initially synthesized and evaluated as adenosine nucleoside analogues for cancer and viral therapy. Recently, designing drugs with pyrazolo[3,4-d]pyrimidine nucleus as pharmacophore encourage different biological activities. This bibliographic development presents an overview on works carried out on pyrazolo[3,4-d]pyrimidine derivatives during the period 2017-2021. There were different reported procedures for synthesis of pyrazolo[3,4-d]pyrimidine either by using its main precursors pyrazole or pyrimidine ring as starting materials or by other miscellaneous routes such as one pot synthesis or Diel's alder reaction. Also, the predicted biological activity of pyrazolopyrimidine nucleus was recorded and the results revealed the ability of pyrazolopyrimidine ring to be active against many cancer cells beside its significant anti-inflammatory, antimicrobial, antimycobacterial, antimalarial, antiviral, anti-gout and anti-diabetic activities. Anticancer activity is the most common use of pyrazolopyrimidine ring through inhibition of different targets and different enzymes that play an important roles in cancer development.
Keywords
Pyrazolo[3,4-d]pyrimidine; Synthesis; Biological activity
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