Synthesis and Identification of Chiral open-chain sugar-derived nitrones and their 1,3-Dipolar Cycloaddition with maleimide and maleic acid | ||
| Egyptian Journal of Chemistry and Environmental Health | ||
| Volume 2, Issue 1, May 2016, Pages 64-74 PDF (446.63 K) | ||
| Document Type: Scientific and Research | ||
| DOI: 10.21608/ejceh.2016.232411 | ||
| Authors | ||
| Usama S. Altimari* ; Arwa Al.Adroay | ||
| College of Health and Medical Technology, Baghdad, IRAQ | ||
| Abstract | ||
| The chiral open-chain sugar-derived nitrones (a,b) were prepared in a pure form. N-Sugar-derived isoxazolidines (2a,b-3a,b)) were synthesized regiospecifically by 1,3-dipolar cycloaddition reaction of a nitrone (a,b) with maleimide and maleic acid. N-sugar-derived isoxazolidine (3a) showed high activity against staphylococcus aurous, and Escherichia coli and complete inhibition of growth against pathogenic fungi candida albicans and microsporum gypseum | ||
| Keywords | ||
| sugar-derived nitrones; 1; 3-dipolar cycloaddition; N-sugarderived isoxazolidines | ||
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