Synthesis and characterization of Erythromycin loaded PLGA and PCL microspheres: Antimicrobial application | ||
| Microbial Biosystems | ||
| Article 6, Volume 6, Issue 2, December 2021, Pages 43-52 PDF (687.56 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mb.2022.122642.1051 | ||
| Authors | ||
| Lamia Bennabi* 1; Ilham Abedlmalek2; Abedelkader Ammari3; Khaldia Sediri4; Fatima Bennabi5; Kaddour Guemra1 | ||
| 1Laboratory of Organic Chemistry, Physics, and Macromolecules (LCOPM), University of Sidi Bel Abbes, Sidi Bel Abbes, Algeria. | ||
| 2Department of Chemistry, Faculty of Matter Sciences, University of Tiaret, Tiaret, Algeria. | ||
| 3Laboratory of Micro and Nanophysics (LaMiN), National Polytechnic School of Oran (ENPO), Oran, Algeria. | ||
| 4Laboratory of Applied Chemistry (LAC), University of Ain Temouchent, Ain Temouchent, Algeria. | ||
| 5Department of Medicine, University of Saad Dahlb, Blida, Algeria. | ||
| Abstract | ||
| We present in this work the preparation of several formulations based on biocompatible biodegradable polymers: polycaprolactone (PCL) and poly (lactic-co-glycolic) acid (PLGA) loaded with Erythromycin(ERYT) antibiotic. These biocompatible materials were used to pre-pare microspheres with and without immobilized ERYT via the simple evaporation method and simple emulsion. The particle size was determined by scanning electron microscopy and the absence of the interaction with ERYT was confirmed via X-ray diffraction and infrared spectroscopy. The release kinetics of ERYT were studied and then, ERYT loaded PCL and PLGA blends microspheres were used for the inhibition of gram-positive S. aureus strain. The microbial activity was carried out by the agar diffusion disc method. The results show that PCL/PLGA blend and only PCL inhibited the bacteria strain by ERYT present in kinetic aliquots with the complementary effect of the polymers. A numerical model was proposed for modeling the kinetics reported in our study. | ||
| Keywords | ||
| Biodegradable polymers; Erythromycin; Microspheres; release kinetics; antibacterial activity | ||
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