Balanites aegyptiaca (Heglig Dates) Reduces Oxidative Stress and Biophysical Alterations of Erythrocyte Membranes in Streptozotocin-Induced Diabetic Rats | ||
| Journal of Advanced Pharmacy Research | ||
| Article 3, Volume 6, Issue 2, April 2022, Pages 78-83 PDF (457.09 K) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/aprh.2022.125054.1151 | ||
| Author | ||
| Naglaa Ismail* | ||
| Physics Department, Biophysics Division, Faculty of Women for Arts, Science and Education, Ain Shams University. Cairo, Egypt. | ||
| Abstract | ||
| Objectives: In diabetic conditions, hyperglycemia-induced oxidative stress promotes alterations of function and other properties of the erythrocyte membrane. In this study, we investigated the effects of Balanites aegyptiaca (100 mg/kg) on biophysical characteristics of erythrocyte membranes in streptozotocin-induced diabetic rats. Methods: Twenty-four male rats were divided into three groups as follows: Group 1, control group; Group 2, diabetic group; and Group 3, diabetic plus Balanites aegyptiaca (Heglig dates). After 30 days of treatment, we determined erythrocyte osmotic fragility, AC conductivity, auto-oxidation rate of hemoglobin, and electron paramagnetic resonance. Results: The osmotic fragility was significantly higher in the diabetic group compared to the control and diabetic with Heglig dates. We also found a significant decrease in the hemoglobin concentration. Conclusion: Four weeks of daily supplementation with 100 mg/kg Heglig dates suggest the beneficial role of Balanites aegyptiaca fruit as a hypoglycemic and could reduce the levels of oxidative stress markers by inhibiting lipid peroxidation in streptozotocin-induced diabetic rats. | ||
| Keywords | ||
| Balanites aegyptiaca; Erythrocytes; Osmotic fragility; EPR signals; Diabetic | ||
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