Extended oral care can prevent oral mucositis in immunocompromised acute lymphoblastic leukemia ghildren
Gamal, A., Abd El Mabood, S., Shalan, H., Mansour, A. (2022). Extended oral care can prevent oral mucositis in immunocompromised acute lymphoblastic leukemia ghildren. EKB Journal Management System, 6(1), 11-17. doi: 10.21608/jcbr.2021.93085.1228
Aya Gamal; Suzy Abd El Mabood; Hanaa Mahmoud Shalan; Ahmed Kamal Mansour. "Extended oral care can prevent oral mucositis in immunocompromised acute lymphoblastic leukemia ghildren". EKB Journal Management System, 6, 1, 2022, 11-17. doi: 10.21608/jcbr.2021.93085.1228
Gamal, A., Abd El Mabood, S., Shalan, H., Mansour, A. (2022). 'Extended oral care can prevent oral mucositis in immunocompromised acute lymphoblastic leukemia ghildren', EKB Journal Management System, 6(1), pp. 11-17. doi: 10.21608/jcbr.2021.93085.1228
Gamal, A., Abd El Mabood, S., Shalan, H., Mansour, A. Extended oral care can prevent oral mucositis in immunocompromised acute lymphoblastic leukemia ghildren. EKB Journal Management System, 2022; 6(1): 11-17. doi: 10.21608/jcbr.2021.93085.1228

Extended oral care can prevent oral mucositis in immunocompromised acute lymphoblastic leukemia ghildren

Egyptian Journal of Cancer and Biomedical Research
Article 2, Volume 6, Issue 1, March 2022, Page 11-17  XML PDF (874.11 K)
Document Type: Original Article
DOI: 10.21608/jcbr.2021.93085.1228
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Authors
Aya Gamal1; Suzy Abd El Mabood email 2; Hanaa Mahmoud Shalan3; Ahmed Kamal Mansour4
1Master of Pediatrics, Mansoura University Children Hospital
2Pediatric Hematology and Oncology Unit, Pediatric Department, Faculty of Medicine, Mansoura University, Egypt
3Pediatric Dentistry Unit, Faculty of Dentistry, Mansoura University, Egypt
4Pediatric Hematology and Oncology Unit, Pediatric department, Faculty of Medicine ,Mansoura University,Egypt
Abstract
Background: Oral mucositis is a serious complication of chemotherapy. The incidence of chemotherapy induced mucositis ranges from 40%-76% with many studies suggesting that children are more susceptible than adults. Aim: We aimed at evaluating pretreatment dental rehabilitation in protecting from oral mucositis in acute lymphoblastic leukemia children.  Patients and Methods: An open labeled randomized controlled study including 50 newly diagnosed patients with dental caries was conducted. They were classified into a group (A) using standard oral care and group (B) undergoing extended oral care using dental rehabilitation by a pediatric dentist before induction chemotherapy. Results: No differences were observed between both groups regarding mucositis development or severity. Mucositis was more among patients with lower neutrophil count, platelet count and poor compliance to daily oral care (P value <0.001, 0.01 and <0.001) respectively. A positive correlation between mucositis grade and Decayed; Missing and Filled Teeth (DMFT) score and a negative correlation between mucositis grade and neutrophil count were noticed with statistical significance. Conclusion: Although dental rehabilitation before induction chemotherapy did not seem to reduce either the occurrence or grade of oral mucositis, the positive correlation between mucositis severity and DMF score supports the importance of pretreatment dental assessment and rehabilitation in such immunocompromised patients. Neutropenia, thrombocytopenia and poor oral care were found to be risk factors for oral mucositis. 
Keywords
Acute lymphoblastic leukemia, ALL, Chemotherapy, Dental rehabilitation; Extended oral care; Immunocompromised children, Mucositis; Standard oral care
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