Advanced-Platelet-Rich Fibrin Combination with Metformin for Surgical Correction of Periodontal Intrabony Defects: A Randomized Double Blinded Clinical Trial
Kamel, A., Abdelrahman, A., Gobran, H., Dameer, H., Badawy, M., Hussein, A. (2021). Advanced-Platelet-Rich Fibrin Combination with Metformin for Surgical Correction of Periodontal Intrabony Defects: A Randomized Double Blinded Clinical Trial. EKB Journal Management System, 12(4), 267-277. doi: 10.21608/omx.2022.128859.1156
Asem Kamel; Ahmed Abdelrahman; Hany Gobran; Hesham Dameer; Mohamed Badawy; Ahmed Hussein. "Advanced-Platelet-Rich Fibrin Combination with Metformin for Surgical Correction of Periodontal Intrabony Defects: A Randomized Double Blinded Clinical Trial". EKB Journal Management System, 12, 4, 2021, 267-277. doi: 10.21608/omx.2022.128859.1156
Kamel, A., Abdelrahman, A., Gobran, H., Dameer, H., Badawy, M., Hussein, A. (2021). 'Advanced-Platelet-Rich Fibrin Combination with Metformin for Surgical Correction of Periodontal Intrabony Defects: A Randomized Double Blinded Clinical Trial', EKB Journal Management System, 12(4), pp. 267-277. doi: 10.21608/omx.2022.128859.1156
Kamel, A., Abdelrahman, A., Gobran, H., Dameer, H., Badawy, M., Hussein, A. Advanced-Platelet-Rich Fibrin Combination with Metformin for Surgical Correction of Periodontal Intrabony Defects: A Randomized Double Blinded Clinical Trial. EKB Journal Management System, 2021; 12(4): 267-277. doi: 10.21608/omx.2022.128859.1156

Advanced-Platelet-Rich Fibrin Combination with Metformin for Surgical Correction of Periodontal Intrabony Defects: A Randomized Double Blinded Clinical Trial

Egyptian Journal of Oral and Maxillofacial Surgery
Article 5, Volume 12, Issue 4, October 2021, Pages 267-277    PDF (486.85 K)
Document Type: Original Article
DOI: 10.21608/omx.2022.128859.1156
Authors
Asem Kamel1; Ahmed Abdelrahman2; Hany Gobran3; Hesham Dameer3; Mohamed Badawy3; Ahmed Hussein* 4
1Oral Medicine, Periodontology, Oral Diagnosis, and Dental Radiology, Faculty of Dental Medicine, Al-Azhar University (Assiut branch), Assiut, Egypt
2Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Al-Azhar University(Assiut branch), Assiut, Egypt
3Oral Biology Department, Assiut University, Assiut, Egypt
4Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Assiut University, Assiut, Egypt
Abstract
Objective: This trial preformed to evaluate clinically and radiographically, the efficacy of growth factors producing/inducing
materials; Advanced-Platelet-Rich Fibrin (A-PRF) and Metformin (MF) respectively, in the surgical treatment of intrabony
periodontal defects.
Methods: Forty-eight systemically healthy chronic periodontitis patients with intrabony defect were divided equally into 4
groups. First Group, patients treated by open flap debridement (OFD). Second Group, patients treated by OFD + 1% MF gel.
Third Group, patients treated by A-PRF, which inserted into the intra bony defect (IBD). Fourth Group treated by (1% MF +
A-PRF). Parameters were gathered at baseline 6 and 9 months.
Results: The reduction in probing depth (PD) and clinical attachment level (CAL) was greater in the A-PRF + 1% MF patients
group than other groups. Combination of A-PRF + 1% MF showed statistically significant reduction of IBD greater than all
other groups.
Conclusions: Usage of combination of A-PRF + 1% MF seems to be superior in gaining bone than surgical treatment by OFD,
OFD + A-PRF or OFD + MF only.
Keywords
Advanced-Platelet-Rich Fibrin; Metformin; Periodontitis; Intrabony Defects; Regeneration; Randomized Clinical Trial
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