Prognostic relevance of immunohistochemical expression of Sox2, YAP1, and IMP3 in non-muscle invasive bladder cancer | ||
| Zagazig University Medical Journal | ||
| Article 28, Volume 28, Issue 6, November 2022, Pages 1414-1429 PDF (1.51 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2022.133357.2555 | ||
| Authors | ||
| Hanaa Mohamed Ibrahim1; Aziza E. Abdelrahman* 2; Amira Elwan3; Eman Ali Elsebai4; Ahmed Eliwa5; Samah S. Elbasateeny6 | ||
| 1Pathology faculty of medicine Zagazig university | ||
| 2Pathology department, faculty of medicine, zagazig university, Egypt | ||
| 3clinical oncology, faculty of medicine | ||
| 4Clinical oncology department | ||
| 5Urology department , Zagazig University | ||
| 6pathology department,faculty of medicine,zagazig university,Egypt | ||
| Abstract | ||
| BACKGROUND: Despite advances in intravesical therapy and surgery, up to 30% of NMIBC suffer progression to MIBC. OBJECTIVES: To identify the valuable prognostic biomarkers, we analyzed the immunohistochemical expression of Sox2, YAP1, and IMP3 in 60 cases of NMIBC who underwent TURBT with adjuvant intravesical bacillus-Calmette-Guerin (BCG). METHODS: The immunohistochemical expression was done on a sixty patients who complained from primary papillary superficial transitional cell carcinoma (TCC) of the urinary bladder (Stage Ta-T1).Their predicting role for recurrence, progression, progression-free survival (PFS), and recurrence-free survival (RFS) was assessed. RESULTS: High Sox2 expression was observed in 55% of NMIBC cases, and it was significantly associated with the tumor size, grade, and stage (p < /p> | ||
| Keywords | ||
| Sox2; YAP1; IMP3; Non-muscle-invasive bladder cancer; Prognostic markers | ||
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