Biochemical Impacts of Treating Diabetic Rats with Irradiated Cinnamon | ||
| Egyptian Journal of Radiation Sciences and Applications | ||
| Article 11, Volume 31, Issue 2, December 2018, Pages 195-204 PDF (605.39 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejrsa.2018.6005.1055 | ||
| Authors | ||
| Mohamed Abd el-Megid1; Ashraf Mounir2; A. Abdul Azeem* 3; A. el-Shahat3 | ||
| 1Natural Products Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt | ||
| 2Food Irradiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA), Cairo, Egypt | ||
| 3Food irradiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA), Cairo, Egypt | ||
| Abstract | ||
| T HE OBJECTIVES of the present study are to evaluate the effect of γ-radiation on total phenolic contents of cinnamon dried powder (CDP) and also to investigate the role of raw and γ-irradiated cinnamon extract (CE) in ameliorating biological disturbances in alloxan-induced diabetic rats. The results obtained show that γ-irradiation (10kGy) increases the total phenolic contents of CDP by percent change 6.39%. The results revealed also that alloxan administration to rats (150mg/kg B.WT) showed a significant increase in the levels of serum glucose, urea, creatinine, uric acidconcomitant with a significant decrease in the levels of insulin, testosterone (T), serum total thyroid hormones triiodothyronin (T3) and thyroxine (T4). Furtherer more, alloxan induced asignificant elevation in lipid peroxidation and a reduction in glutathione content and antioxidant enzyme activities in the renal and testicular tissues of diabetic rats. Treatment of diabetic rats with either raw or γ-irradiated CE has significantly ameliorated the alteration in the antioxidant/oxidant status and improved hyperglycemia, renal, and endocrine abnormalities. In conclusion, the study indicated that cinnamon, in addition to being hypoglycaemic, is effective in reducing oxidative stress caused by alloxan-induceddiabetes and the γ-irradiation of CPE increased its hygienic quality and significantly its total phenolic content without a significant loss in its quality attributes. | ||
| Keywords | ||
| Cinnamon; antioxidants; diabetes; alloxan; Oxidative Stress; gamma radiation | ||
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