The Association of Prothrombin G20210 Gene Polymorphism and Risk of Thrombosis in B.Thalassemic Children in Egypt
fawzy, A., hesham, M., Ali, A., abougabal, S., Abd elnour, H. (2024). The Association of Prothrombin G20210 Gene Polymorphism and Risk of Thrombosis in B.Thalassemic Children in Egypt. EKB Journal Management System, 30(2), 513-521. doi: 10.21608/zumj.2022.128050.2526
amal fawzy; mervat hesham; Adel Ali; shimaa abougabal; Hanim Abd elnour. "The Association of Prothrombin G20210 Gene Polymorphism and Risk of Thrombosis in B.Thalassemic Children in Egypt". EKB Journal Management System, 30, 2, 2024, 513-521. doi: 10.21608/zumj.2022.128050.2526
fawzy, A., hesham, M., Ali, A., abougabal, S., Abd elnour, H. (2024). 'The Association of Prothrombin G20210 Gene Polymorphism and Risk of Thrombosis in B.Thalassemic Children in Egypt', EKB Journal Management System, 30(2), pp. 513-521. doi: 10.21608/zumj.2022.128050.2526
fawzy, A., hesham, M., Ali, A., abougabal, S., Abd elnour, H. The Association of Prothrombin G20210 Gene Polymorphism and Risk of Thrombosis in B.Thalassemic Children in Egypt. EKB Journal Management System, 2024; 30(2): 513-521. doi: 10.21608/zumj.2022.128050.2526

The Association of Prothrombin G20210 Gene Polymorphism and Risk of Thrombosis in B.Thalassemic Children in Egypt

Zagazig University Medical Journal
Article 28, Volume 30, Issue 2, March and April 2024, Page 513-521  XML PDF (751.43 K)
Document Type: Original Article
DOI: 10.21608/zumj.2022.128050.2526
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Authors
amal fawzy email 1; mervat heshamorcid 2; Adel Ali3; shimaa abougabal4; Hanim Abd elnour5
1Medical Biochemistry Department- Faculty of Medicine - Zagazig University
2Pediatric Department, Faculty of Medicine, Zagazig University
3Faculty of Medicine, Zagazig University, Department of Pediatrics, Sharkia Egypt
4Pediatric Department ,Faculty of Medicine ,Zagazig University
5Medical Biochmestry Department, Faculty of Medicine, Zagazig Univerisity, Zagazig, Egypt
Abstract
Background: Hypercoagulable state is associated with thalassemic children with increased risk of thromboembolic events ,There are multiple factors are contributing to hypercoagulable state in thalassemia patient.
Aim of the study: To assesses the prothrombin G20210A gene polymorphism in Egyptian thalassemic children being additional risk factor for thromboembolism in thalssemic children .

Methods: This is a case control study. It included 40 thalassemic patients with thromboembolic manifistation and 40 healthy controls. The prothrombin gene polymorphism was identified using a restriction fragment length polymerase chain reaction (RFLP PCR).
Results: No Significant difference in prothrombin G20210A genotype between Thalssemic patient with thrombotic manifistation and controls regarding allele and genotype distributions. (OR 3.2 , 95 % CI 0.57–17.89 and p=0.082 for AA genotype ). A allele was significantly related to cases (25% in cases in comparison to 12.5% in controls).
Conclusion: prothrombin gene polymorphism has no role predisposition to thalassemic coagulability in thalassemic Egyptian children.
Keywords
Thalassemia; prothrombin gene; thromboembolism, polymorphism
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