The Association of Prothrombin G20210 Gene Polymorphism and Risk of Thrombosis in B.Thalassemic Children in Egypt | ||
| Zagazig University Medical Journal | ||
| Article 28, Volume 30, Issue 2, March and April 2024, Pages 513-521 PDF (751.43 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2022.128050.2526 | ||
| Authors | ||
| amal fawzy* 1; mervat hesham2; Adel Ali3; shimaa abougabal4; Hanim Abd elnour5 | ||
| 1Medical Biochemistry Department- Faculty of Medicine - Zagazig University | ||
| 2Pediatric Department, Faculty of Medicine, Zagazig University | ||
| 3Faculty of Medicine, Zagazig University, Department of Pediatrics, Sharkia Egypt | ||
| 4Pediatric Department ,Faculty of Medicine ,Zagazig University | ||
| 5Medical Biochmestry Department, Faculty of Medicine, Zagazig Univerisity, Zagazig, Egypt | ||
| Abstract | ||
| Background: Hypercoagulable state is associated with thalassemic children with increased risk of thromboembolic events ,There are multiple factors are contributing to hypercoagulable state in thalassemia patient. Aim of the study: To assesses the prothrombin G20210A gene polymorphism in Egyptian thalassemic children being additional risk factor for thromboembolism in thalssemic children . Methods: This is a case control study. It included 40 thalassemic patients with thromboembolic manifistation and 40 healthy controls. The prothrombin gene polymorphism was identified using a restriction fragment length polymerase chain reaction (RFLP PCR). Results: No Significant difference in prothrombin G20210A genotype between Thalssemic patient with thrombotic manifistation and controls regarding allele and genotype distributions. (OR 3.2 , 95 % CI 0.57–17.89 and p=0.082 for AA genotype ). A allele was significantly related to cases (25% in cases in comparison to 12.5% in controls). Conclusion: prothrombin gene polymorphism has no role predisposition to thalassemic coagulability in thalassemic Egyptian children. | ||
| Keywords | ||
| Thalassemia; prothrombin gene; thromboembolism, polymorphism | ||
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