SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME THIAZOLIDINONEDERIVATIVES BEARING PYRIDINE MOIETY: SEARCH FOR ANTIMIROBIAL AGENT | ||
| Al-Azhar Bulletin of Science | ||
| Article 9, Volume 2014, Issue 12, December 2014, Pages 31-40 PDF (605.85 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/absb.2014.23797 | ||
| Authors | ||
| Ali Khalil* 1; Raafat A. Elisway2; H. A. Eyada2; Hazem A. Mohamed2; Gameel A. El-Hag Ali2 | ||
| 1Departments of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt | ||
| 2Departments of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo(boys) Egypt | ||
| Abstract | ||
| 2-(4-Oxothiazolidin-2-ylidene)acetonitrile and ethyl -2-(4-oxothiazolidin-2-ylidene)acetate (1a,b),were condensed with anthralaldehyde(1:1 molar ratio) and gave 4,5-dihydro- 4-oxothiazole derivatives (2a,b).Refluxingof 2-(antharacene- 9-yl-methylene) malononitrile in acetic acid with thioglycollic acid gave(3).4-Thiaz -olidinones containing bis- aryl methylidine moieties(4a-c) and (5a,b)were produced via condensation of either(2a) or (3) with aromatic aldehydes(1:1 molar ratio). Heating of (2a) with α-substituted cinnamonitriles gave the expected substituted thiazolo[3,2-a] pyridines (6a-d),(7) and (9a-c). Thiazolo [3,2-a] pyridine enamino- nitrile (6a) was refluxed with formic acid and phenyl hydrazine to form the corres-ponding thiazolo [3,2-a] pyridine derivatives (10) and (11) derivatives respectively.The structures of the prepared compounds were confirmed by using spectroscopic techniques; IR; 1HNMR ;13C NMR and Mass spectroscopy. Also, Anibactreial and antifungal activity were evaluated for some of synthesized compounds. | ||
| Keywords | ||
| 4-Thiazolidinones, thiazolo [3, 2-a] pyridines; and anthracene | ||
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