Effect of Intrapartum Hyoscine Butylbromide Administration on Duration of Labor and Mode of Delivery: A Systematic Review and Meta - Analysis | ||
| Evidence Based Women's Health Journal | ||
| Article 12, Volume 12, Issue 2, May 2022, Pages 218-230 PDF (1.1 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ebwhj.2022.127680.1172 | ||
| Authors | ||
| Eman Gomaa1; Abdel Rahman Shabaan2; Eslam Mohamed1; Ahmed Saleh3; Omar Mohammed4; Mohamed Ramadan5; Amr Hussein* 5 | ||
| 1MBBCh, Medicine and Surgery, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| 2MBBCh, Medicine and Surgery, Faculty of Medicine, Cairo University, Cairo, Egypt | ||
| 3MBBCh, Medicine and Surgery, Faculty of Medicine, Alexandria University, Alexandria, Egypt | ||
| 4MBBCh, Medicine and Surgery, Faculty of Medicine, Fayoum University, Fayoum, Egypt | ||
| 5MD, Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt | ||
| Abstract | ||
| Background: Hyoscine Butylbromide (HBB) is a potent parasympatholytic drug with strong antispasmodic action contributing to cervical dilation during labor. Objective: We aimed to determine if hyoscine butylbromide (HBB) during labor is associated with shortened duration of labor. Search Strategy: We searched several electronic databases from inception to march 2019 using various search terms. Selection Criteria: Randomized controlled trials comparing HBB vs. placebo regarding labor duration. Data Collection and Analysis: After screening and data extraction, mean difference with 95% confidence interval (CI) for continuous data and odds ratio with 95% CI for categorical data were calculated. Main Results: Fourteen articles (2287 patients) were included. HBB shortens durations of first stage (MD = -60.86, 95% CI [-82.89 to -38.84]), second stage (MD = -3.18, 95% CI [-5.12 to -1.24]) and third stage of labor (MD = -0.84, 95% CI [-1.19 to -0.50]). Indeed, overall rate of cervical dilatation was greater in HBB group (MD= 0.65-minute, 95% CI, 0.51 to 0.80). However, HBB does not affect the rate of vaginal or cesarean deliveries. Conclusions: Hyoscine Butylbromide shortens the duration of all stages of labor and increases the rate of cervical dilatation. However, it does not affect the mode of delivery | ||
| Keywords | ||
| Buscopan; cervical dilatation; HBB; labor duration; meta-analysis | ||
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