Synthesis, Anticancer and Antimicrobial Activities of New 6-(1H-1,2,3-Triazol-4-yl)imidazo[2,1-b]thiazoles | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 2, February 2023, Pages 223-230 PDF (779.29 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2022.138240.6078 | ||
| Authors | ||
| Bakr F Abdel-Wahabb* 1; Hanem Awad2; Ghada Awad3; Hanan M Mohamed4 | ||
| 1Applied Organic Chemistry Department, Chemical Industries Research Institute, National Research Center, Dokki, Giza, 12622 Egypt | ||
| 2Tanning Materials and Leather Technology Department, National Research Centre, Egypt | ||
| 3Pharmaceutical and Drug Industries Research division | ||
| 4Applied organic chemistry Department; National Research Centre; Egypt | ||
| Abstract | ||
| Novel 6-(1H-1,2,3-triazol-4-yl)-imidazo[2,1-b]thiazoles 8-10 were synthesized in good yields by Claisen–Schmidt reaction of the active methylene compounds such as pyrazol-5-one 5, 1,3-indandione 6 and benzoylaceteonitrile 7, with imidazo[2,1-b]thiazol-5-aldehydes 4 in basic medium. Anti-tumor activities in vitro against HepG-2, PC-3 and HCT-116 human carcinoma cell lines were tested for new products. Both compounds 9a and 9b showed antitumor activity comparable to that of positive control (Doxorubicin®). Also, the antimicrobial activities of novel compounds were evaluated. Amongst the tested compounds 9a, 9b, and 10 exhibited excellent antimicrobial activity. | ||
| Keywords | ||
| 1,2,3-Triazole; Anticancer; Antimicrobial activity, Single crystal x-ray | ||
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