Synthesis, Anticancer and Antimicrobial Activities of New 6-(1H-1,2,3-Triazol-4-yl)imidazo[2,1-b]thiazoles
Abdel-Wahabb, B., Awad, H., Awad, G., Mohamed, H. (2023). Synthesis, Anticancer and Antimicrobial Activities of New 6-(1H-1,2,3-Triazol-4-yl)imidazo[2,1-b]thiazoles. EKB Journal Management System, 66(2), 223-230. doi: 10.21608/ejchem.2022.138240.6078
Bakr F Abdel-Wahabb; Hanem Awad; Ghada Awad; Hanan M Mohamed. "Synthesis, Anticancer and Antimicrobial Activities of New 6-(1H-1,2,3-Triazol-4-yl)imidazo[2,1-b]thiazoles". EKB Journal Management System, 66, 2, 2023, 223-230. doi: 10.21608/ejchem.2022.138240.6078
Abdel-Wahabb, B., Awad, H., Awad, G., Mohamed, H. (2023). 'Synthesis, Anticancer and Antimicrobial Activities of New 6-(1H-1,2,3-Triazol-4-yl)imidazo[2,1-b]thiazoles', EKB Journal Management System, 66(2), pp. 223-230. doi: 10.21608/ejchem.2022.138240.6078
Abdel-Wahabb, B., Awad, H., Awad, G., Mohamed, H. Synthesis, Anticancer and Antimicrobial Activities of New 6-(1H-1,2,3-Triazol-4-yl)imidazo[2,1-b]thiazoles. EKB Journal Management System, 2023; 66(2): 223-230. doi: 10.21608/ejchem.2022.138240.6078

Synthesis, Anticancer and Antimicrobial Activities of New 6-(1H-1,2,3-Triazol-4-yl)imidazo[2,1-b]thiazoles

Egyptian Journal of Chemistry
Volume 66, Issue 2, February 2023, Page 223-230  XML PDF (779.29 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.138240.6078
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Authors
Bakr F Abdel-Wahabb email 1; Hanem Awadorcid 2; Ghada Awad3; Hanan M Mohamed4
1Applied Organic Chemistry Department, Chemical Industries Research Institute, National Research Center, Dokki, Giza, 12622 Egypt
2Tanning Materials and Leather Technology Department, National Research Centre, Egypt
3Pharmaceutical and Drug Industries Research division
4Applied organic chemistry Department; National Research Centre; Egypt
Abstract
Novel 6-(1H-1,2,3-triazol-4-yl)-imidazo[2,1-b]thiazoles 8-10 were synthesized in good yields by Claisen–Schmidt reaction of the active methylene compounds such as pyrazol-5-one 5, 1,3-indandione 6 and benzoylaceteonitrile 7, with imidazo[2,1-b]thiazol-5-aldehydes 4 in basic medium. Anti-tumor activities in vitro against HepG-2, PC-3 and HCT-116 human carcinoma cell lines were tested for new products. Both compounds 9a and 9b showed antitumor activity comparable to that of positive control (Doxorubicin®). Also, the antimicrobial activities of novel compounds were evaluated. Amongst the tested compounds 9a, 9b, and 10 exhibited excellent antimicrobial activity.
Keywords
1,2,3-Triazole; Anticancer; Antimicrobial activity, Single crystal x-ray
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