Assessment of Seminal L-Carnitine in Infertile Men with Varicocele
Aabdallah, M., Ibrahim, T., Abugabal, K., AboSief, A. (2022). Assessment of Seminal L-Carnitine in Infertile Men with Varicocele. EKB Journal Management System, 3(2), 243-252. doi: 10.21608/ejmr.2022.241699
Mohamed Adel Aabdallah; Taymour Mostafa Ibrahim; Khadiga Mohamed Abugabal; Ahmed Fathy Mohamed AboSief. "Assessment of Seminal L-Carnitine in Infertile Men with Varicocele". EKB Journal Management System, 3, 2, 2022, 243-252. doi: 10.21608/ejmr.2022.241699
Aabdallah, M., Ibrahim, T., Abugabal, K., AboSief, A. (2022). 'Assessment of Seminal L-Carnitine in Infertile Men with Varicocele', EKB Journal Management System, 3(2), pp. 243-252. doi: 10.21608/ejmr.2022.241699
Aabdallah, M., Ibrahim, T., Abugabal, K., AboSief, A. Assessment of Seminal L-Carnitine in Infertile Men with Varicocele. EKB Journal Management System, 2022; 3(2): 243-252. doi: 10.21608/ejmr.2022.241699

Assessment of Seminal L-Carnitine in Infertile Men with Varicocele

Egyptian Journal of Medical Research
Article 17, Volume 3, Issue 2, April 2022, Pages 243-252    PDF (343.58 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2022.241699
Authors
Mohamed Adel Aabdallah1; Taymour Mostafa Ibrahim2; Khadiga Mohamed Abugabal3; Ahmed Fathy Mohamed AboSief1
1Andrology, Sexology & STIs Faculty of Medicine, Beni-Suef University
2Andrology, Sexology & STIs Faculty of Medicine, Cairo University
3Clinical and Chemical Pathology Faculty of Medicine, Beni-Suif University
Abstract
Introduction: Most studies that linked varicocele (Vx) with male infertility focused mainly on the testis affection, yet it was suggested that Vx can disturb also the epididymis that plays a central role in sperm maturation. Higher concentrations of L-Carnitine (LC) were reported in the human epididymis but few studies have investigated the relationship of seminal LC with male infertility associated with Vx. This study aimed to assess seminal plasma L-Carnitine (LC) levels in infertile oligoathenoteratozoospermic (OAT) patients with varicocele (Vx). Methods: Overall, 86 men were investigated. They were divided into; infertile OAT patients with Vx (n=45), infertile OAT patients without Vx (n=21), and fertile men (n=20) as controls. These cases were subjected to history taking, clinical examination, and semen analysis. Seminal LC levels were estimated by the colorimetric method. Results: The mean seminal plasma LC levels were significantly lower in infertile OAT patients with Vx (216.3 ± 57.1 ng/ml) compared to infertile OAT patients without Vx  (252.9 ± 62.9 ng/ml, P= 0.01), or fertile men (382.8 ± 63.6 ng/ml, P=0.001). Besides, the mean seminal plasma LC level exhibited significant decreases in infertile OAT patients of Vx grade III compared to Vx grade II cases, and in infertile OAT patients of bilateral Vx compared with unilateral Vx cases. Collectively, there was a significant positive correlation between seminal LC levels with sperm concentration, motility, and normal forms. Conclusion: Seminal LC levels are expressively reduced in infertile OAT patients with Vx influenced by an escalation of its grade and bilaterality.
Keywords
male infertility; Vx; carnitine
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