Synthesis, Reactions, and Antimicrobial Evaluation of 2-(1,3-dioxoisoindolin-2-yl)acetohydrazide derivatives | ||||
| Egyptian Journal of Chemistry | ||||
| Article 50, Volume 65, Issue 11, November 2022, Page 541-548 PDF (466.06 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.136934.6037 | ||||
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| Authors | ||||
Ban Hasan Taresh1; Aseel Q Al-saffar2; Ewies F. Ewies   3
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| 1Department of Clinical Laboratories, College of Applied Medical Sciences, University of  Kerbala, Kerbala, Iraq | ||||
| 2College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq | ||||
| 3Organometallic and Organometalloid Chemistry, Chemical Industries Research Institute, National Research Centre | ||||
| Abstract | ||||
| New 2-(1,3-dioxoisoindolin-2-yl)acetohydrazide derivatives were synthesized, characterized and evaluated as antimicrobial agents. Phathalic anhydride was reacted with aminoacetoactate to afford phthalimide derivative which reacted with hydrazine hydrate to give new indolinylacetohydrazide derivative 1. Compound 1 is used as precursor to synthesize various derivatives depending on types of reactants. Spectroscopic and analytical measurements are used to confirm structures of new products. Antimicrobial evaluation of new derivatives was done | ||||
| Keywords | ||||
| acetohydrazide; triazole; thiazolidinone; benzo[e][1; 3]thiazine; Antimicrobial Evaluation | ||||
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