Effect of Ginkgo biloba leaf extract in combination with vitamin C, E and D on Aluminum Chloride induced Alzheimer in rats.
elhallouty, S., Rashad, A., Abd elrhman, E., Elkaramany, H., Ibrahim, M., Salem, N., Adeeb, R., Ibrahim, Y., El Shahed, Z. (2022). Effect of Ginkgo biloba leaf extract in combination with vitamin C, E and D on Aluminum Chloride induced Alzheimer in rats.. EKB Journal Management System, 65(131), 827-841. doi: 10.21608/ejchem.2022.133257.5889
Salwa Mahmoud elhallouty; Anan Mohamed Rashad; Esraa Ayman Abd elrhman; Haidy Amr Khaled Elkaramany; Maria Gamal Ibrahim; Nouran Tamer Salem; Reeny Ayman Adeeb; Yehia Walaa Ibrahim; Zeinab Abd Elkhalek El Shahed. "Effect of Ginkgo biloba leaf extract in combination with vitamin C, E and D on Aluminum Chloride induced Alzheimer in rats.". EKB Journal Management System, 65, 131, 2022, 827-841. doi: 10.21608/ejchem.2022.133257.5889
elhallouty, S., Rashad, A., Abd elrhman, E., Elkaramany, H., Ibrahim, M., Salem, N., Adeeb, R., Ibrahim, Y., El Shahed, Z. (2022). 'Effect of Ginkgo biloba leaf extract in combination with vitamin C, E and D on Aluminum Chloride induced Alzheimer in rats.', EKB Journal Management System, 65(131), pp. 827-841. doi: 10.21608/ejchem.2022.133257.5889
elhallouty, S., Rashad, A., Abd elrhman, E., Elkaramany, H., Ibrahim, M., Salem, N., Adeeb, R., Ibrahim, Y., El Shahed, Z. Effect of Ginkgo biloba leaf extract in combination with vitamin C, E and D on Aluminum Chloride induced Alzheimer in rats.. EKB Journal Management System, 2022; 65(131): 827-841. doi: 10.21608/ejchem.2022.133257.5889

Effect of Ginkgo biloba leaf extract in combination with vitamin C, E and D on Aluminum Chloride induced Alzheimer in rats.

Egyptian Journal of Chemistry
Volume 65, Issue 131, December 2022, Page 827-841  XML PDF (1.43 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.133257.5889
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Authors
Salwa Mahmoud elhallouty1; Anan Mohamed Rashadorcid 2; Esraa Ayman Abd elrhmanorcid 2; Haidy Amr Khaled Elkaramanyorcid 3; Maria Gamal Ibrahimorcid 2; Nouran Tamer Salemorcid 2; Reeny Ayman Adeeborcid 2; Yehia Walaa Ibrahimorcid 2; Zeinab Abd Elkhalek El Shahed email orcid 4
1Pharmacognosy Department, National Research Centre
2Biotechnology Department, Faculty of Science, Cairo University
3Biotechnology Department , Faculty of Science, Cairo University.
4National research center
Abstract
Alzheimer’s disease(AD), is a neurodegenerative ailment and the most prevalent cause of dementia. The commonly used synthetic drugs provide temporary and incomplete symptomatic treatment accompanied with severe side effects. The present study aimed at evaluating the therapeutic potential of Ginko Biloba, and/ or Vitamin D, E, C on aluminum chloride (AlCl3)-induced neurotoxicity in rats.

AD was induced in rats by oral administration of AlCl3 (17 mg/kg BW) for 1 month. Rats were treated with Ginko Biloba methanolic leaf extract (400 mg/kg.BW/day), vitamin D3 (0.0125 mg/kg.BW/day), E(2.5mg/kg.BW/day), Vitamin C (50mg/kg.BW/day) and their combinations, respectively, for 15 days. Behavioral assessment was carried out using Y-maze test. The activity of acetylcholinesterase, Dopamine, Serotonin and Nor-Epinephrine; in addition, histopathological examination of the isolated Hippocampal brain tissues were done. It was observed that administration of Ginko biloba in combination with vitamin C attenuated memory impairment and improved cholinergic and dopaminergic dysfunction. Also, significant improvement in histopathological alterations and hippocampal morphology was noticed. It could be concluded that Ginko biloba and /or vitamin C exhibited significant improvement in memory loss and neurotoxicity and could be an effective treatment against cognitive decline in AD patients.
Keywords
Alzheimer’ s disease; Neurotoxicity; Ginko Biloba; Vitamin C; Y-maze; Neurotransmitter
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