Valvular Calcification in Hemodialysis Cases: Relation to Functional Deficiency of Vitamin K and 25-Hydroxyvit-D Serum Level | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 126, Volume 88, Issue 1, July 2022, Page 3078-3082 PDF (317.41 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2022.244544 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Sherif El Sayed Mansour  ; Ghada Mohamed Hasan Elkanishy; Tarek Medhat Abbas; Ahmed Bahy Eldeen Ibrahim
| ||||
| Abstract | ||||
| Background: Elevated incidence of death in hemodialysis (HD) cases is frequently accompanying with quicker atherosclerosis and increased vascular calcification. Objective: The current study aimed to determine the relation between valvular calcification in HD cases and functional vitamin-K (Vit-K) as presented by serum level of uncarboxylated matrix Gla protein (ucMGP) and 25(OH) vitamin-D (Vit-D) levels. Patients and Methods: This work was conducted over six months and included 90 HD cases and 20 apparently healthy adults with normal kidney function (to establish normal range of ucMGP); age and gender matched to the HD cases. Results: About one-third of the patients (41.1%) had calcifications on the aortic valve, and about one-quarter had calcifications on the mitral valve (27.8%). Non-significant association was noted between MGP and vit-D (P = 0.439). Conclusion: We suggested that the end-stage renal disease (ESRD) in HD is accompanied by a shortage levels of vit-K and vit-D built in present work. The most important result of the present work was the significant difference in MGP between patients and controls, suggesting a correlation between MGP level and aortic valve calcifications. | ||||
| Keywords | ||||
| Hemodialysis; Serum Level; Vit-K; 25-Hydroxyvit-D | ||||
|
Statistics Article View: 264 PDF Download: 355 |
||||
