HISTOLOGICAL EFFECTS OF HERBICIDE (MACHETE) 0 THE KIDNEY OF ALBINO RAT | ||||
| Journal of Plant Protection and Pathology | ||||
| Article 1, Volume 28, Issue 6, June 2003, Page 5043-5051 PDF (1.09 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jppp.2003.244697 | ||||
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| Authors | ||||
| Fatma S. EI-Mahrouky,1; Fatma K. Khidr1; S. M. Abdel-Aal2; H. A. Zedan1 | ||||
| 1Plant Protection Research Institute, ARC, Dokkl-Glza . | ||||
| 2Faculty of Agrtc., AL - Azhar Univ., Asslut., Egypt. | ||||
| Abstract | ||||
| The histological changes and some parameters in the kidney of albino rat re examined to show the effect of daily 1/4 lD50 (500 mg/kg b.w,) of herbicide Mac~~te afttir 151. 2.J)d, 3!d and 4th weeks post Ireatment. The results indicated a marlted SignifICant decrease in body weight, while a significant increase in kidney weight. Kidney ; Hyperaemia was observed in the cortical blood vessels, while he epithelial cells lining the renal tubules had degenerative changes. Focal mononucl~ar leucocytic Inflammatory caUs infiltration was noticed inbetween the renal tubulel. It could be stated that Machete herbicide causes pathogenesis In kidney tissue I at could possiblY leads to renal dysfunction. . Also, total protein, total bilirubin, uric acid creatinine and urea were change in plasma of albino rat after oral administration 1/4 L050 herticlde Machete daily, it was observed an increase in total bilirubin, uric acid, c:teatinine and urea but a gradually decreases was recorded in total protein level at an tested periods, except at1stwe k creatinine did not changed compared with control. | ||||
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