The Association between Catalase Gene rs1001179 and rs769217 Polymorphisms and The Hepatocellular Carcinoma Risk in the Egyptian Patients | ||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||
| Article 40, Volume 14, Issue 1, June 2022, Pages 475-487 PDF (653.37 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsc.2022.245915 | ||
| Authors | ||
| Mohammad Elkhamy1; Gamal Badra2; Moustafa A. Sakr3; Amal A. Abdel Aziz1; Mahmoud Lotfy1 | ||
| 1Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt. | ||
| 2Hepatology and Internal Medicine, National liver Institute, Minufiya University. | ||
| 3Molecular Diagnostics and Therapeutics Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt. | ||
| Abstract | ||
| Using a thorough case-control design, we evaluated whether CAT SNPs were hepatocellular carcinoma (HCC) risk factors in the current study. Employing PCR-RFLP analysis, the genotypes of CAT rs1001179 and rs769217 were determined in 50 HCC-diagnosed patients and 50 healthy controls. CAT rs1001179 distributions revealed considerable variations between both groups, either in terms of allelic or genotypic distribution, since TT genotypes and the T allele differed significantly between the examined groups. Regarding the CAT rs769217, there were also significant differences in TT genotypes and T allele between the studied groups In Conclusion, the collected information characterized the CAT gene in HCC patients in Egypt for the first time and associations between CAT gene rs1001179 (262C/T) and CAT rs769217 (389C/T) and the propensity to HCC. | ||
| Keywords | ||
| CAT gene; hepatocellular carcinoma; Single nucleotide polymorphisms; PCR-RFLP | ||
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