Heterocyclization and Biological Evaluation of Malonic Hydrazide; Novel Synthesis of Some Azoles and Azines | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 3, March 2023, Pages 479-482 PDF (375.25 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/ejchem.2022.147813.6399 | ||
| Authors | ||
| Mohamed H Abd El-Azim1; mohammed gomma assy2; Maha Ahmed Elmesalamy* 3; Yasser Selim4 | ||
| 1Department of Chemistry, Faculty of Science, Zagazig University, Egypt. | ||
| 2Department of Chemistry, Faculty of Science, Zagazig University, (Egypt) | ||
| 3Department of Chemistry - Zagazig University - Zagazig- Egypt | ||
| 4Chemistry Department, Faculty of Specific Education. Zagazig University | ||
| Abstract | ||
| Cyclocondensation of malonic hyrazide with two equimolar of dibenzal acetophenone 2 resulted in cyclohexane pyrazole 4 presumably via the non-isolable aza Michel product 3 followed by losing H2O. Three equivalent amount of benzoyl isothiocynate and malonic hydrazide undergo Michel and two Aza Michel addition providing poly thiourea derivative 6.The hydrazone type 7 cyclocondensed with two mole of CS2 to furnish pyridazine derivative 9. Nitrosation of target 7 resulted in hydrazone of type 11 that cyclized to oxadiazine 12. Compound 7 undergo Michel addition to hetero allene followed by cyclization yielding pyrimidine 15. | ||
| Keywords | ||
| Malonic hydrazide; azines; azoles; condensed system; polythiourea | ||
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