Leptin in Egyptian Children with CKD: A Single Center Experience.
Sallam, D., Younis, R., Abdel-Wahed, M., Elhenawy, Y., El-Khayat, S. (2022). Leptin in Egyptian Children with CKD: A Single Center Experience.. EKB Journal Management System, 17(1), 58-69. doi: 10.21608/geget.2022.249900
Dina Ebrahem Sallam; Rawan Ahmed Younis; Marwa Ali Abdel-Wahed; Yasmine Ibrahim Elhenawy; Samer Hamed El-Khayat. "Leptin in Egyptian Children with CKD: A Single Center Experience.". EKB Journal Management System, 17, 1, 2022, 58-69. doi: 10.21608/geget.2022.249900
Sallam, D., Younis, R., Abdel-Wahed, M., Elhenawy, Y., El-Khayat, S. (2022). 'Leptin in Egyptian Children with CKD: A Single Center Experience.', EKB Journal Management System, 17(1), pp. 58-69. doi: 10.21608/geget.2022.249900
Sallam, D., Younis, R., Abdel-Wahed, M., Elhenawy, Y., El-Khayat, S. Leptin in Egyptian Children with CKD: A Single Center Experience.. EKB Journal Management System, 2022; 17(1): 58-69. doi: 10.21608/geget.2022.249900

Leptin in Egyptian Children with CKD: A Single Center Experience.

GEGET
Article 6, Volume 17, Issue 1, June 2022, Page 58-69  XML PDF (250.47 K)
Document Type: Original Article
DOI: 10.21608/geget.2022.249900
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Authors
Dina Ebrahem Sallam email orcid 1; Rawan Ahmed Younis2; Marwa Ali Abdel-Wahed3; Yasmine Ibrahim Elhenawy4; Samer Hamed El-Khayat5
1Department of Pediatrics, Pediatric Nephrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
2Department of Pediatrics , Faculty of Medicine, Ain Shams University, Cairo, Egypt.
3Department of Clinical Pathology Faculty of Medicine, Ain Shams University, Cairo, Egypt.
4Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
5Department of Pediatrics , Faculty of Postgraduate Childhood studies, Ain Shams University, Cairo, Egypt.
Abstract
Introduction: Leptin, is an anorexigenic hormone that’s secreted by fat tissue, & affect appetite.                                          Aim of the study: The present study evaluated serum leptin level, & its relation to growth parameters in pediatric patients with different stages of CKD. 
Methods: a cross-sectional study that was conducted on 87 subjects, who were divided into 3 groups equally; CKD stage 5 on regular hemodialysis (CKD5d), & CKD stage 2-4, & age & gender matched controls. Patient with diabetes, infected with hepatitis C virus, & on growth hormone therapy were excluded. Full history taking, assessment of growth parameters using gender & age specific Z-scores of heights, weight & body mass index were done. Fasting serum leptin, calcium, phosphorus, PTH, albumin, total proteins, iron & hemoglobin were measured. 
Results: Our patients had significantly lower growth parameters compared to controls. Hypocalcemia, high PTH, iron deficiency anemia & hypoalbuminemia were significant in CKD2-4 groups compared to other groups. Serum leptin was abnormally high in 12.6% of CKD patients. The median leptin level was comparable between the groups (p=0.20). Serum leptin hadn’t changed significantly as regards gender, BMI Z-scores, diagnoses, or CKD stage (p= 1.00, 0.379, 0.542, 0.171 respectively). A negative correlation was found between leptin level & CKD duration (r = -0.276, P = 0.036), otherwise, no correlations were found with clinical & laboratory variables. 
Conclusion & recommendations: Leptin level was not affected by CKD stage & not a useful marker for growth in pediatric CKD patients. Large studies on relationship between leptin & growth are needed.
Keywords
BMI; CKD; Leptin; Z-scores
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