Leptin in Egyptian Children with CKD: A Single Center Experience. | ||
| GEGET | ||
| Article 6, Volume 17, Issue 1, June 2022, Pages 58-69 PDF (250.47 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/geget.2022.249900 | ||
| Authors | ||
| Dina Ebrahem Sallam* 1; Rawan Ahmed Younis2; Marwa Ali Abdel-Wahed3; Yasmine Ibrahim Elhenawy4; Samer Hamed El-Khayat5 | ||
| 1Department of Pediatrics, Pediatric Nephrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||
| 2Department of Pediatrics , Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||
| 3Department of Clinical Pathology Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||
| 4Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||
| 5Department of Pediatrics , Faculty of Postgraduate Childhood studies, Ain Shams University, Cairo, Egypt. | ||
| Abstract | ||
| Introduction: Leptin, is an anorexigenic hormone that’s secreted by fat tissue, & affect appetite. Aim of the study: The present study evaluated serum leptin level, & its relation to growth parameters in pediatric patients with different stages of CKD. Methods: a cross-sectional study that was conducted on 87 subjects, who were divided into 3 groups equally; CKD stage 5 on regular hemodialysis (CKD5d), & CKD stage 2-4, & age & gender matched controls. Patient with diabetes, infected with hepatitis C virus, & on growth hormone therapy were excluded. Full history taking, assessment of growth parameters using gender & age specific Z-scores of heights, weight & body mass index were done. Fasting serum leptin, calcium, phosphorus, PTH, albumin, total proteins, iron & hemoglobin were measured. Results: Our patients had significantly lower growth parameters compared to controls. Hypocalcemia, high PTH, iron deficiency anemia & hypoalbuminemia were significant in CKD2-4 groups compared to other groups. Serum leptin was abnormally high in 12.6% of CKD patients. The median leptin level was comparable between the groups (p=0.20). Serum leptin hadn’t changed significantly as regards gender, BMI Z-scores, diagnoses, or CKD stage (p= 1.00, 0.379, 0.542, 0.171 respectively). A negative correlation was found between leptin level & CKD duration (r = -0.276, P = 0.036), otherwise, no correlations were found with clinical & laboratory variables. Conclusion & recommendations: Leptin level was not affected by CKD stage & not a useful marker for growth in pediatric CKD patients. Large studies on relationship between leptin & growth are needed. | ||
| Keywords | ||
| BMI; CKD; Leptin; Z-scores | ||
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