Spectrophotometric Determination of Loratadine drug by New 6-hydrazineyl-3-(pyridiin-4-yl)-[1,2,4] triazolo[3, 4-b][1, 3 ,4]thiadiiazole A1 derived from isonicotinic acid in pure and pharmaceuticals formulation | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 65, Issue 132, December 2022, Page 273-280 PDF (1.19 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.122082.5467 | ||||
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| Authors | ||||
Asmaa Ahmed Mohammed   1; shaimaa hatem abdullah 2; Ghazwan Hasan Abdulwahhab 2
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| 1department of chemistry, college of education, university of Tikrit | ||||
| 2Department of chemistry/College of Education for Pure Science / Tikrit University /Iraq | ||||
| Abstract | ||||
| A novel, sensitive, simple, and accurate spectrophotometric technique for the determination of Loratadine (LD) drug in pure and pharmaceutical formulations was developed. It was created by the reaction of (LD) and a new organic reagent (A1) prepared from (TCH) and (A) in a base medium. TCH was prepared by heating at reflux of a mixture of carbon disulfide and aqueous hydrazine, while (A) was prepared by thermal melting of a mixture of TCH and nicotinic acid. The absorption of the product of LD and A1 was measured at 466 nm. Linearity ranged between (0.625-30μg.mL-1), molar absorptivity was (17918.92 L / mol.cm), limits of detection and quantification were (0.0705, 0.213 μg.ml-1), respectively. The method was applied successfully for the determination of LD in pure and pharmaceutical formulations. | ||||
| Keywords | ||||
| Determination; Isonicotinic acid; Loratadine; Spectrophotometric; Thiocarbohydrazide | ||||
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