PRELIMINARY STUDY FOR THE EFFECT OF TRAMADOL ADDICTION ON FUNCTIONAL AND STRUCTURAL INTEGRITY OF RENAL PROXIMAL TUBULES AMONG ADDICTED EGYPTIANS
El-Safty, I., Elgamel, O., El-Rasheed, A., Sadek, H., Shoman, A., El-Deen, I., El-Ashmawy, M. (2014). PRELIMINARY STUDY FOR THE EFFECT OF TRAMADOL ADDICTION ON FUNCTIONAL AND STRUCTURAL INTEGRITY OF RENAL PROXIMAL TUBULES AMONG ADDICTED EGYPTIANS. EKB Journal Management System, 2014(6), 39-44. doi: 10.21608/absb.2014.25180
I. A. El-Safty; O. Elgamel; A. H. El-Rasheed; H. Sadek; A. E. Shoman; I. E. El-Deen; M. F. El-Ashmawy. "PRELIMINARY STUDY FOR THE EFFECT OF TRAMADOL ADDICTION ON FUNCTIONAL AND STRUCTURAL INTEGRITY OF RENAL PROXIMAL TUBULES AMONG ADDICTED EGYPTIANS". EKB Journal Management System, 2014, 6, 2014, 39-44. doi: 10.21608/absb.2014.25180
El-Safty, I., Elgamel, O., El-Rasheed, A., Sadek, H., Shoman, A., El-Deen, I., El-Ashmawy, M. (2014). 'PRELIMINARY STUDY FOR THE EFFECT OF TRAMADOL ADDICTION ON FUNCTIONAL AND STRUCTURAL INTEGRITY OF RENAL PROXIMAL TUBULES AMONG ADDICTED EGYPTIANS', EKB Journal Management System, 2014(6), pp. 39-44. doi: 10.21608/absb.2014.25180
El-Safty, I., Elgamel, O., El-Rasheed, A., Sadek, H., Shoman, A., El-Deen, I., El-Ashmawy, M. PRELIMINARY STUDY FOR THE EFFECT OF TRAMADOL ADDICTION ON FUNCTIONAL AND STRUCTURAL INTEGRITY OF RENAL PROXIMAL TUBULES AMONG ADDICTED EGYPTIANS. EKB Journal Management System, 2014; 2014(6): 39-44. doi: 10.21608/absb.2014.25180

PRELIMINARY STUDY FOR THE EFFECT OF TRAMADOL ADDICTION ON FUNCTIONAL AND STRUCTURAL INTEGRITY OF RENAL PROXIMAL TUBULES AMONG ADDICTED EGYPTIANS

Al-Azhar Bulletin of Science
Article 5, Volume 2014, Issue 6, June 2014, Pages 39-44    PDF (120.92 K)
Document Type: Original Article
DOI: 10.21608/absb.2014.25180
Authors
I. A. El-Safty* 1; O. Elgamel2; A. H. El-Rasheed2; H. Sadek2; A. E. Shoman3; I. E. El-Deen4; M. F. El-Ashmawy4
1Departments of Biochem. Sec., Chem., Faculty of Education, Ain Shams University
2Institute of Psychiatry, Ain Shams University
3Community, Environmental and Occupation Med., Fac. of Med., Ain Shams University
4Faculty of Science, Port-Saed University.
Abstract
Experimental animals and human post-mortem studies concerning renal effects of tramadol addiction showed histopathological changes in proximal tubules. This study investigates early changes in function and structure of proximal tubules to tramadol addiction. The study included 44 males (G1 = 23 controls, G2 = 21 tramadol addicts). The measured urinary parameters were: urinary alpha-1-microglobulin (U.1-m), urinary leucine aminopeptidase (U.LAP), urinary N-acetyl--D-glucosaminidase (U.NAG). Urinary tramadol (U.Tr) was measured in G2. In G2, levels of U.1-m, U.LAP and U.NAG were increased in comparison with G1. These changes were insignificant. U.Tr did not show any correlation with any parameter in G2. Tramadol addiction may affect proximal tubules. This study is a Preliminary assessment for the subclinical renal effects of tramadol.
Keywords
Alpha-1-microglobulin; tramadol; Leucine aminopeptidase; N-acetyl-beta-D-glucosaminidase; Nephrotoxicity
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