Comparative study between fixed and flexible GnRH antagonist protocol versus GnRH agonist long protocol in polycystic ovarian disease patients treated with IVF
Abd-Elaal, H., Kassab, F., Deif, O., Mira, I., Essawy, M. (2019). Comparative study between fixed and flexible GnRH antagonist protocol versus GnRH agonist long protocol in polycystic ovarian disease patients treated with IVF. EKB Journal Management System, 74(4), 858-866. doi: 10.21608/ejhm.2019.25265
Hany Maged Abd-Elaal; Farid Ahmed Kassab; Osama Deif; Ismael Abd-Elazeem Mira; Mohamed Mohamed Mohamed Essawy. "Comparative study between fixed and flexible GnRH antagonist protocol versus GnRH agonist long protocol in polycystic ovarian disease patients treated with IVF". EKB Journal Management System, 74, 4, 2019, 858-866. doi: 10.21608/ejhm.2019.25265
Abd-Elaal, H., Kassab, F., Deif, O., Mira, I., Essawy, M. (2019). 'Comparative study between fixed and flexible GnRH antagonist protocol versus GnRH agonist long protocol in polycystic ovarian disease patients treated with IVF', EKB Journal Management System, 74(4), pp. 858-866. doi: 10.21608/ejhm.2019.25265
Abd-Elaal, H., Kassab, F., Deif, O., Mira, I., Essawy, M. Comparative study between fixed and flexible GnRH antagonist protocol versus GnRH agonist long protocol in polycystic ovarian disease patients treated with IVF. EKB Journal Management System, 2019; 74(4): 858-866. doi: 10.21608/ejhm.2019.25265

Comparative study between fixed and flexible GnRH antagonist protocol versus GnRH agonist long protocol in polycystic ovarian disease patients treated with IVF

The Egyptian Journal of Hospital Medicine
Article 19, Volume 74, Issue 4, January 2019, Page 858-866  XML PDF (468.97 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.25265
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Authors
Hany Maged Abd-Elaal1; Farid Ahmed Kassab1; Osama Deif1; Ismael Abd-Elazeem Mira1; Mohamed Mohamed Mohamed Essawy2
1Obstetrics and Gynecology department, Faculty of Medicine, Al-Azhar University
2Obstetrics and Gynecology Department, Beni-Suef General Hospital, Ministry of Health, Egypt.
Abstract
The objective of the present study was to compare and evaluate the effectiveness and safety of GnRH agonist long protocol compared with the GnRH antagonist (fixed and flexible) protocols in polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) cycles. This study was carried out on 60 patients with polycystic ovarian disease undergoing ICSI, their age ranged from (20 to 40 years). The cases were selected from The International Center for Population Study and Research (ICPS), Al-Azhar University.  Eligible patients who accepted to take part in the study were randomized into 3 study group: Group A:  20 patients were included in agonist protocol, Group B: 20 patients were included in fixed antagonist protocol and Group C: 20 patients were included in flexible antagonist protocol. The results obtained from this study indicated no statistically significant differences regarding the pregnancy rates or regarding the developing of ovarian hyperstimulation syndrome (OHSS) complication in the studied population; so larger studies with larger sample size and longer duration are needed to clarify the roles of different IVF protocols.
Keywords
gonadotropin-releasing hormone agonist; gonadotropin-releasing hormone antagonist; in vitro fertilization; Polycystic Ovarian Syndrome
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