ACRYLAMIDE INDUCED GENOTOXIC EFFECT IN GOLDEN HAMSTER (Mesocricetus auratus) GENOME | ||||
| Journal of Plant Production | ||||
| Article 11, Volume 28, Issue 9, September 2003, Page 6701-6711 PDF (565 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jpp.2003.252718 | ||||
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| Authors | ||||
| D. Y. Al-Ayoubi,1; M. A. Seehy2 | ||||
| 1Girl’s College of Education, Genetics , Riyadh, Saudia | ||||
| 2Dept. of Genetics , Fac. Of Agric. , Alexandria Univ. , Egypt | ||||
| Abstract | ||||
| This work aims at dislosing the capability of acrylamide in causing genotoxic effect in golden hamster genome. To achieve such a purpose, five different doses that ranged from 1 to 20 mg/ kg b. wt. were chosen and tested employing three genotoxic bioassays. These assays are : 1-Estimation of cell proliferation, 2-Analysis of chromosomal abnormalities; and 3-In vivo induction of sister chromatid exchanges. The results obtained showed that all tested doses were found to be toxic and cellular toxicity was observed. Analysis o chromosomal aberrations revealed that acrylamide is a positive clastogenic agent. Sister chromatid exchange assay indicated that acrylamide is a powerful inducer of primary genetic damage. | ||||
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