Unveiling The Anti-Alzheimer, Antioxidant, Anti-Inflammatory, Antiviral Therapeutic Functionality Of Polysaccharides Extracted From Opuntia Ficus
Murad, S., Abd-Elshafy, D., Abou Baker, D., Bahgat, M., Ibrahim, E., Gaafar, A., Salama, Z. (2023). Unveiling The Anti-Alzheimer, Antioxidant, Anti-Inflammatory, Antiviral Therapeutic Functionality Of Polysaccharides Extracted From Opuntia Ficus. EKB Journal Management System, 66(5), 237-244. doi: 10.21608/ejchem.2022.148208.6435
Soha Ahmed Murad; Dina N. Abd-Elshafy; Doha H Abou Baker; Mahmoud M. Bahgat; Eman Ahmed Ibrahim; Alaa Abdallah Gaafar; Zeinab Salama. "Unveiling The Anti-Alzheimer, Antioxidant, Anti-Inflammatory, Antiviral Therapeutic Functionality Of Polysaccharides Extracted From Opuntia Ficus". EKB Journal Management System, 66, 5, 2023, 237-244. doi: 10.21608/ejchem.2022.148208.6435
Murad, S., Abd-Elshafy, D., Abou Baker, D., Bahgat, M., Ibrahim, E., Gaafar, A., Salama, Z. (2023). 'Unveiling The Anti-Alzheimer, Antioxidant, Anti-Inflammatory, Antiviral Therapeutic Functionality Of Polysaccharides Extracted From Opuntia Ficus', EKB Journal Management System, 66(5), pp. 237-244. doi: 10.21608/ejchem.2022.148208.6435
Murad, S., Abd-Elshafy, D., Abou Baker, D., Bahgat, M., Ibrahim, E., Gaafar, A., Salama, Z. Unveiling The Anti-Alzheimer, Antioxidant, Anti-Inflammatory, Antiviral Therapeutic Functionality Of Polysaccharides Extracted From Opuntia Ficus. EKB Journal Management System, 2023; 66(5): 237-244. doi: 10.21608/ejchem.2022.148208.6435

Unveiling The Anti-Alzheimer, Antioxidant, Anti-Inflammatory, Antiviral Therapeutic Functionality Of Polysaccharides Extracted From Opuntia Ficus

Egyptian Journal of Chemistry
Volume 66, Issue 5, May 2023, Pages 237-244    PDF (410.19 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.148208.6435
Authors
Soha Ahmed Murad* 1; Dina N. Abd-Elshafy2; Doha H Abou Baker3; Mahmoud M. Bahgat4; Eman Ahmed Ibrahim1; Alaa Abdallah Gaafar1; Zeinab Salama1
1Plant Biochemistry Department , Agricultural and Biology Research Institute, National Research Centre, Dokki, Cairo
2Immune and Biomarkers for Infection (CEAS), National Research Centre
3Medicinal and Aromatic Plant Department, National Research Centre (NRC), 33 EL Bohouth St. (Former El Tahrir St.), Dokki, Giza, Egypt, P.O.1262.
4Therapeutic Chemistry Department, National Research Centre (NRC), 33 EL Bohouth St. (Former El Tahrir St.), Dokki, Giza, Egypt, P.O.1262
Abstract
Opuntia ficus peels or Prickly pear peel (PPP) is the waste byproduct obtained during fruit processing, the present study aims to extract polysaccharides from PPP and analyze it by HPLC. The biological potential activities as antioxidant, anti-inflammatory, antiviral, and anti Alzheimer of these polysaccharides were examined. Polysaccharides were extracted from PPP using hot water. Its composition was analyzed by HPLC. Profiles of 14 different natural mono sugars were identified. Stachyose, galactose, xylose, and sucrose were the most abundant sugars. Results indicated that the polysaccharides of PPP extract have antioxidant activity against DPPH and ABTS free radical. The scavenging activity of (150 µg /ml) of polysaccharides appeared to be interesting compared to synthetic antioxidants. Polysaccharides of PPP had 77.77% anti-inflammatory activity which is caused by inhibiting the heat-induced albumin denaturation and anti-Alzheimer effect (42.02%) compared to Donepezil drug (59.50%) in a dose-dependent manner. On the other hand polysaccharides of PPP extract showed no activity when tested against HSV-1 and Influenza A by plaque reduction assay. Thus, it could be suggested that polysaccharides PPP demonstrated potential biological activities as an antioxidant, anti-inflammatory, and anti-Alzheimer activities.
Keywords
Opuntia ficus peels; polysaccharides bioactivity; HPLC
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