Staphylococcus Aureus Nasal Colonization in the Neonatal Intensive Care Unit of Beni-Suef University Hospital
Abdel-Aziz, M., Fahmey, S., Ibrahim, N., Mabrouk, A. (2022). Staphylococcus Aureus Nasal Colonization in the Neonatal Intensive Care Unit of Beni-Suef University Hospital. EKB Journal Management System, 3(3), 117-129. doi: 10.21608/ejmr.2022.254588
Mervat Abdel-Baseer Tohamy Abdel-Aziz; Sameh Samir Fahmey; Nermin Hassan Ibrahim; Amna Gouda Mabrouk. "Staphylococcus Aureus Nasal Colonization in the Neonatal Intensive Care Unit of Beni-Suef University Hospital". EKB Journal Management System, 3, 3, 2022, 117-129. doi: 10.21608/ejmr.2022.254588
Abdel-Aziz, M., Fahmey, S., Ibrahim, N., Mabrouk, A. (2022). 'Staphylococcus Aureus Nasal Colonization in the Neonatal Intensive Care Unit of Beni-Suef University Hospital', EKB Journal Management System, 3(3), pp. 117-129. doi: 10.21608/ejmr.2022.254588
Abdel-Aziz, M., Fahmey, S., Ibrahim, N., Mabrouk, A. Staphylococcus Aureus Nasal Colonization in the Neonatal Intensive Care Unit of Beni-Suef University Hospital. EKB Journal Management System, 2022; 3(3): 117-129. doi: 10.21608/ejmr.2022.254588

Staphylococcus Aureus Nasal Colonization in the Neonatal Intensive Care Unit of Beni-Suef University Hospital

Egyptian Journal of Medical Research
Volume 3, Issue 3, July 2022, Page 117-129  XML PDF (506.93 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2022.254588
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Authors
Mervat Abdel-Baseer Tohamy Abdel-Aziz1; Sameh Samir Fahmey2; Nermin Hassan Ibrahim1; Amna Gouda Mabrouk2
1Medical Microbiology and Immunology Department, Faculty of Medicine, Beni-Suef University, Egypt
2Pediatrics department, Faculty of Medicine, Faculty of Medicine, Beni-Suef University, Egypt
Abstract
Staphylococcus aureus (S. aureus) remains one of the most frequently occurring community-acquired as well as hospital-acquired pathogens with high rates of hospital-acquired infections.  S.aureus is an important pathogenic bacterium. It resides predominantly in the anterior nares, and extra-nasal sites including the skin, perineum, and pharynx, and less frequent in the gastrointestinal tract and the vagina. About 30% of the general population is nasal carriers of the bacterium. Infections caused by this organism could be exogenous or endogenous in origin, and they include impetigo, cellulitis, osteomyelitis, endocarditis, toxic shock syndrome (TSS), septicemia, and pneumonia.  Healthcare-associated infections by S. aureus are about 20% worldwide. S. aureus infection at NICU remains a major health challenge as colonized healthcare workers, patients, and contaminated surfaces serve as reservoir for infection. The incidence of healthcare-associated infections caused by S. aureus continues to increase worldwide. The goal of this study is to assess the nasal carriage of S. aureus isolated from neonates and health care workers (HCWs) in the NICU of Beni Suef University Hospital. Also, our study provides valuable insights documenting important factors that affect susceptibility and outcomes of neonatal sepsis which is a global public health issue.
Keywords
Nasal S. aureus carrier; NICU; HCWs; Neonatal sepsis
References
  1. Blencowe H, Cousens S, Oestergaard M, Chou D, Moller AB, Narwal R, Adler A, Garcia CV, Rohde S, Say L,  and Lawn JE. National, regional and worldwide estimates of preterm birth. The Lancet. 2012; 379(9832):2162-72
  2. Matary A, Heena H, AlSarheed AS, Ouda W, AlShahrani DA, Wani TA, et al. (2019): Characteristics of neonatal Sepsis at a tertiary care hospital in Saudi Arabia. J Infect Publ Health 2019; 12(5): 666e672.
  3. Quddus AR, Islam MN, Uddin MB, Mahmud AA, Badruzzaman M, Saha SK, et al. (2019): Study of Risk Factors, Causative Organisms & Their Sensitivity Pattern in Neonatal Sepsis in a Community Based Tertiary Level Hospital. Mymensingh Med J [Internet]. 2019 Oct [cited 2020 Apr 8]; 28(4):839–48.
  4. Garba B, Muhammad A, Mohammed B, Obasi A, Adeniji A. (2017): A study of neonatal mortality in a specialist hospital in Gusau, Zamfara, North-Western Nigeria. Int J Trop Dis Heal. 2017;28:1–6. 
  5. Edwards MS, Baker CJ. (2014): Sepsis in the newborn, p 545–561. In Gershon AA, Hotez PJ, Katz SL (ed), Krugman’s infectious diseases of children, 11th ed. Mosby, Philadelphia, PA.
  6. Kluytmans J, van Belkum A, Verbrugh H. (2019): Nasal carriage of aureus: epidemiology, underlying mechanisms and associated risks. Clin Microbiol Rev. July 2019;10 (3):505–20. 
  7. Paul MO, Lamikanra A, Aderibigbe DA. (2019): Nasal carriers of coagulase positive staphylococci in a Nigerian hospital community. R. Soc. Trop. Med. Hyg. 2019;76 (3):319–23.
  8. Popoola VO, Budd A, Wittig SM, et al. (2014): aureus Transmission and Infections in a Neonatal Intensive Care Unit despite Active Surveillance Cultures and Decolonization: Challenges for Infection Prevention. Infect Control Hosp Epidemiol. 2014;35(04): 412–418.
  9. Leshem E, Maayan-Metzger A, Rahav G, et al. (2012): Transmission of aureus from mothers to newborns. Pediatr Infect Dis J 2012;31:360–3. 
  10. Jimenez-Truque N, Tedeschi S, Saye EJ, et al. (2012): Relationship between maternal and neonatal Staphylococcus aureus colonization. Pediatrics 2012; 129: e1252–9. 
  11. Iacobelli S, Colomb B, Bonsante F, Astruc K, Ferdynus C, Bouthet MF, et al. (2013): Successful control of a aureus outbreak in a neonatal intensive care unit: a retrospective, before-after study. BMC Infect Dis. 2013;13(1):440. 
  12. World Health Organization. (2016): Five moments for hand hygiene. Geneva: World Health Organization; 2016 (http:// who.int/gpsc/ tools/Five_ moments/en/).
  13. Arias CA, Reyes J, Carvajal LP, Rincon S, Diaz L, Panesso D, et al. (2017): A prospective cohort multicenter study of molecular epidemiology and phylogenomics of  aureusbacteremia in nine Latin American countries. Antimicrob Agents Chemother. 2017;61(10). 
  14. van Hal SJ, Jensen SO, Vaska VL, Espedido BA, Paterson DL, Gosbell IB.(2012): Predictors of mortality in  aureusbacteremia.Clin Microbiol Rev. 2012;25(2):362–86.  
  15. Martínez Aguilar G. Análisis de genotipos y de los tiempos (2010): duplicación de cepas de aureusresistente de infecciones nosocomiales y adquiridas en la comunidad. Diss. PhD thesis. México: Universidad de Colima; 2010.
  16. Zervou FN, Zacharioudakis IM, Ziakas PD, Mylonakis E. (2012): aureus colonization and risk of infection in the neonatal and pediatric ICU: a meta-analysis. Pediatrics. 2014;133(4):e1015–23.
  17. Gesualdo F, Bongiorno D, Rizzo C, Bella A, Menichella D, Stefani S, et al. (2013): SA nasal colonization in children: prevalence meta-analysis, review of risk factors and molecularPediatr Infect Dis J. 2013;32 (5):479–85.
  18. Marimuthu K, Pittet D, Harbarth S. (2014): The effect of improved hand hygiene on nosocomial MRSA control. Antimicrob Resist Infect Control. 2014;3:34.
  19. Dramowski, A. Madide, and A. Bekker, (2015): “Neonatal nosocomial bloodstream infections at a referral hospital in a middle-income country: burden, pathogens, antimicrobial resistance and mortality,” Paediatrics and International Child Health, vol. 35, no. 3, pp. 265–272, 2015.
  20. Pierce R, Lessler J, Popoola VO, Milstone AM. (2017): aureus acquisition risk in an endemic neonatal intensive care unit with an active surveillance culture and decolonization programme. J Hosp Infect. 2017; 95(1):91–97.
  21. Kresimir M, Hana D, Matej S, Krunoslav M, Katarina P, Vvesna M, Karolina K (2017): Causes of respiratory distress among neonates of gestational age 32 weeks and more. Journal in Intensive Care And Emergency Medicine, 13(4): 21 – 24.
  22. Cochi SE, Kempker JA, Annangi S, et al (2016): Mortality trends of acute respiratory distress syndrome in the United States from 1999–2013. Ann Am Thorac Soc., 13: 1742–1751.
  23. Mike S., JOLANTA W. and ANNA S. (2014): Serum and Urinary examination in Newborns, Bio. Med. Research International, (24): 1-8, 2014.  
  24. EL-Shimi M.S., MOHAMED M.H., ABDEL AL AHMED, et al. (2014): Human Neutrophil Lipocalin in Early Diagnosis of Neonatal diseass. Egyptian Journal of Pediatrics, 394 (3587): 1-15, 2014.
  25. Nabila Ibrahim Abd El-Megeed Laza , Mohamed Nabil Salemb , Hebatullah Kamal Ebraheem Tahaa , Mona Mahmoud Sroura (2020): Studying the characteristics of interstitial pneumonia with auto immune features Chest diseases and tuberculosis, Faculty of Medicine, Beni Suef University, Egypt. Internal medicine. Rheumatology & Immunology, Faculty of Medicine, Beni Suef University, Egypt. Egyptian Journal of Medical Research (EJMR), Volume 1, Issue2, 2020.
  26. Anna CS, Hannah B, Alexander AM, et al. (2014): Estimates of possible severe bacterial infection in neonates in sub-Saharan Africa, South Asia, and Latin America for 2012: a systematic review and meta-analysis. Lancet. 2014; 14: 731 –40.
  27. Abd El Haleim M. Mona, Nada N. Nawar, Eman M. Abd El Rahman, Heba H. Abo Hussein and Nermin R. Mohamed Kamel (2019): Epidemiologic and Micro-bacteriologic Study of Neonatal Septicaemia in Cairo University Neonatal Intensive Care Units Clinical Pathology Department, Faculty of Medicine, Cairo University, Egypt Research Journal of Medicine and Medical Sciences: no. 18, pp. 1093–1147, 2019.
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