N-Acetylcysteine encapsulated niosomes as antitumor nanoparticles. | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 5, May 2023, Pages 379-384 PDF (475.93 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2022.155918.6745 | ||
| Authors | ||
| Abeer A. Ali1; Reem El-Gebaly2; Ebtesam A. Mohamad* 1 | ||
| 1Biophysics Department, Faculty of Science, Cairo University, Egypt. | ||
| 2Department of Biophysics, Faculty of Science, Cairo University, Cairo, Egypt | ||
| Abstract | ||
| N-Acetylcysteine (NAC) is an antioxidant compound with antitumor properties. In this study NAC was encapsulated into niosomes for treatment tumor in mice. NAC- encapsulated niosomes’ morphology and Fourier-transform infrared spectroscopy (FTIR) analysis were measured. Fifteen mice male BALB/c were divided to three groups: group1: negative control, group2 positive control (tumor group), group3 treated with NAC- encapsulated niosomes after tumor growth. The effect of NAC- encapsulated niosomes on the tumor was determined by measuring tumor size progress, comet assay, oxidative stress parameters (GSH, Nitric Oxide, histopathological investigation. Transmission electron microscopy examination found that NAC- encapsulated niosomes have spherical shape. Tissues histological studies emphasized the protective effect of NAC- encapsulated niosomes against tumor. In conclusion oral delivery of NAC- encapsulated niosomes improved antitumor effect. | ||
| Keywords | ||
| Niosomes; N-Acetylcysteine; Tumor; Histopathology | ||
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