Effect of Enteral Propranolol in Acute Traumatic Brain Injury | ||
| SVU-International Journal of Medical Sciences | ||
| Article 28, Volume 6, Issue 1, January 2023, Pages 263-270 PDF (287.03 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2022.152895.1355 | ||
| Authors | ||
| Gad Sayd Gad1; Ali R. Hamdan2; Marwa Nasreldeen Elansary1; Aya Nassif Abd El-Rheem* 1 | ||
| 1Department of Anesthesia, ICU and Pain Management, Faculty of Medicine, South Valley University, Qena, Egypt. | ||
| 2Department of Neurosurgery, Faculty of Medicine, South Valley University, Qena, Egypt. | ||
| Abstract | ||
| Background: Severe traumatic brain injury (TBI) is the predominant cause of death and disability following trauma. Several studies have observed improved survival in TBI patients exposed to β-blockers. Objectives: To evaluated effect of enteral propranolol on the outcomes of acute traumatic brain injury patients. Patients and methods: Forty patients with acute TBI were enrolled and divided into two group: group I (20 patients) were received 20 mg of oral Propranolol in 10cc water every 12 h for 10 days through nasogastric ryle, the group II (20 patients) were received 10cc water (placebo group). Results: Our results showed statistically significant (p-value < 0.001) increased percentage of neurological deficit in group II (20 patients, 100%) when compared with group I (0 patients, 0%), increased GCS after TTT in group I (12.3 ± 1.6) when compared with group II (7.85 ± 1.03). We also found statistically significant (p-value < 0.001) increased Karnofsky scale in group I (92 ± 6.2) when compared with group II (35.5 ± 5.1). Conclusion: Early enteral propranolol can be used for longer survival and more functional recovery in cases with isolated severe traumatic brain damage. | ||
| Keywords | ||
| GCS; Propranolol; Traumatic Brain Injury | ||
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