SPERM NUCLEAR VACUOLES RATIO AS A DETERMINANT FOR UNEXPLAINED INFERTILITY AND ITS RISK FACTORS | ||
| The Egyptian Journal of Fertility and Sterility | ||
| Article 6, Volume 17, Issue 2 - Serial Number 11106352, June 2013, Pages 28-31 PDF (1.05 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/egyfs.2013.257477 | ||
| Author | ||
| Elham Hussein Madny, Mohamed M farrag, Amro S khodir, Nrmeen kamal* | ||
| Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University | ||
| Abstract | ||
| Objective: To evaluate the role of nuclear vacuole ratio as determinant of unexplained infertility and assessment of its risk factors. Patients and method:This prospective comparative study included two groups of infertile couples: group A included 20 couples with unexplained infertility and group B included 20 couples with secondary infertility due to female factor and normal semen analysis. MSOME was used for further individual sperm retrieval. Vacuoles > 50% of nuclear area were considered large nuclear vacuoles (LNV). Results:55% of males with unexplained infertility have spermatozoa with LNV versus only 10% of males with secondary infertility. It was estimated that odds ratio of presence of LNV among males with unexplained infertility is 11 (95% CI: 1.7 – 115.2). Older age, smoking habit and presence of chronic disease are significant risk factors for presence of spermatozoa with LNV with odd ratio 19.5, 26.7 and 30.3 respectively. Conclusion:Spermatozoa with LNV are potential cause for infertility among couples with unexplained infertility and further research is highly recommended. | ||
| Keywords | ||
| Keywords: Infertility; MSOME; Nuclear vacuoles; Large nuclear vacuoles | ||
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