Impact of Lymphotoxin alpha Gene Polymorphisms on Childhood Asthma | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 72, Volume 89, Issue 1, October 2022, Pages 4587-4591 PDF (545.79 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2022.258691 | ||
| Authors | ||
| Mohamed Sanad Nagiub; Nermeen Samy Mohamed Ahmed* ; Reham Hassan Anis Mohammed; Sahbaa Fehr Mohamed Hafez | ||
| Abstract | ||
| Background: Bronchial asthma, a common allergic disorder among children, is a chronic airway inflammatory disease. Clinically, it tends to occur with recurrent symptoms mainly involve dyspnea, wheezing, cough, and chest distress. Objective: The aim of the study wasto evaluate the association between lymphotoxin alpha (LTα) gene polymorphisms and childhood bronchial asthma. Patients and methods: A case control study was carried out on 116 children divided to 29 control group and 87 cases. Detection of lymphpotoxin alpha gene polymorphism was assessed. Result: There was statistically significant difference between asthma group and control group regarding genotypes (P-value 0.044). There was a statistically significant negative correlation between FEV1 and IgE level, and a significant positive correlation between FEV1 and eosinophilic count. Conclusion: The genetic predisposition is considered one of the important attributable risk factors of childhood asthma. In addition, the polymorphism of lymphotoxin alpha A/G (rs2844484) is correlated with the risk of childhood asthma. | ||
| Keywords | ||
| Lymphotoxin alpha Gene Polymorphisms; lymphotoxin alpha; Childhood Asthma; Risk factors | ||
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