BIOCHEMICAL EFFECTS OF CALCIFEROL RODENTICIDE ON ALBINO MICE | ||
| Journal of Plant Protection and Pathology | ||
| Article 1, Volume 25, Issue 4, April 2000, Pages 2351-2356 PDF (465.86 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jppp.2000.258835 | ||
| Author | ||
| E. A. Eweis, | ||
| Department of Econ. Entomol. and Pesticides, Faculty of Agriculture, Cairo University, Egypt. | ||
| Abstract | ||
| Median lethal dose of Claciferol (Vitamin D) against albino mice Mus musculus was estimated. Calciferol could be classified as a highly toxic compound to albino mice as its LD50 values to the (immature and adult) were 47 and 60 mg/kg, respectively. Three doses representing 1/10, 1/20 and 1/30 of the LD50 were administered orally for 2 weeks. In treated animals the rate of body weight gain, water and food consumption were decreased clearly at 1/10 LD50 of Calciferol than other doses. Similarly, organs weight/body weight ratio was lower than that observed in non-treated animals. Calcium, phosphorus and cholesterol levels were affected. The tissue-specific enzymes alkaline phosphates (AP), the amount of urea, creatinine and total proteins of serum, liver and kidney were significantly increased. | ||
| Keywords | ||
| Calciferol; calcium; phosphorus; (AP); Cholesterol; urea; creatinine and total proteins | ||
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