Novel synthesis of Some Novel Pyrimidine Heterocycles. | ||
| Bulletin of Faculty of Science, Zagazig University | ||
| Article 9, Volume 2022, Issue 2, July 2022, Pages 101-104 PDF (810.84 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfszu.2022.134859.1129 | ||
| Authors | ||
| Wael Farid Metwally* 1; Atef Mohamed Abdel Hamid2; Mohamed G. Assy3; Mohamed Abd El-Azim4 | ||
| 1chemistry,science,zagazig | ||
| 2Department of chemistry, Faculty of science, Zagazig university | ||
| 3Chemistry Dep., Faculty of Science, Zagazig University, Zagazig, Egypt | ||
| 4Department of chemistry, faculty of science, Zagazig university | ||
| Abstract | ||
| The utilization of thioxouracil 1 as a precursor for the synthesis of some novel functionalized and annulated azines was reported here, thus amination of compound 1 afforded diaminopyrimidine scaffold 3 which upon treatment with benzoyl isothiocyanate furnished functionalized pyrimidine 5. Also, diazotization of 3 yielded tetrazolopyrimidine 7. The structures of the newly synthesized compounds were confirmed by different spectral tools. The utilization of thioxouracil 1 as a precursor for the synthesis of some novel functionalized and annulated azines was reported here, thus amination of compound 1 afforded diaminopyrimidine scaffold 3 which upon treatment with benzoyl isothiocyanate furnished functionalized pyrimidine 5. Also, diazotization of 3 yielded tetrazolopyrimidine 7. The structures of the newly synthesized compounds were confirmed by different spectral tools. The utilization of thioxouracil 1 as a precursor for the synthesis of some novel functionalized and annulated azines was reported here, thus amination of compound 1 afforded diaminopyrimidine scaffold 3 which upon treatment with benzoyl isothiocyanate furnished functionalized pyrimidine 5. Also, diazotization of 3 yielded tetrazolopyrimidine 7. The structures of the newly synthesized compounds were confirmed by different spectral tools. | ||
| Keywords | ||
| Diaminopyrimidine; Heterocyclization; Azolopyrimidine; Cycloaddition; Thiouracil | ||
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