Evaluation of Cyclin-Dependent Kinase Inhibitor 2A and Hepatocyte Nuclear Factor-1A Gene Polymorphisms in Coronary Artery Diseases | ||
| Zagazig University Medical Journal | ||
| Article 28, Volume 30, Issue 3, May and June 2024, Pages 859-868 PDF (905.78 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2022.161460.2636 | ||
| Authors | ||
| Magdy ibrahimm1; abdelsalam sherif2; dina salah mohamed* 3; walaa samy1 | ||
| 1medical biochemistry, faculty of medicine, Zagazig university, Egypt | ||
| 2cardiology department, faculty of medicine, Zagazig university, Egypt | ||
| 3medical biochemistry, faculty of medicine,zagazig university, Egypt | ||
| Abstract | ||
| Background: Blood lipid-regulating and cell proliferation-regulating genes have both been connected to the development of coronary artery disease (CAD). Objective: to find the correlation between CDKN2A rs3088440, HNF1A rs55783344CT gene polymorphisms and CAD. Subjects and methods: One hundred and six participants were subjected to this case-control study; case group I: patients with CHD and control group II: Normal healthy people. Subjects underwent a comprehensive history and physical examination, standard laboratory tests, and coronary angiograms. CDKN2A rs3088440 and HNF1A rs55783344CT gene polymorphisms was done by (PCR-RFLP). Results: CT genotype and CT+TT of HNF1AC were statistically Signiant higher in CAD cases than controls. T allele of HNF1AC was much higher in CAD cases than controls, with a significant difference between 2 groups. Proportion of those with the CDKN2A GA+AA genotype in the CAD patients was significantly higher than in the control group. Also, the frequency of the CDKN2A A allele was significantly different between CAD cases and controls. Conclusion: Coronary heart disease (CHD) has a complex etiopathogenesis and a multifactorial origin. SNPs are potential risk factors of CHD. CDKN2A rs3088440 (G>A) and HNF1A rs55783344CT gene polymorphisms be a factor in pathogenesis of CHD | ||
| Keywords | ||
| Coronary Artery Diseases; Cyclin-Dependent Kinase Inhibitor 2A; Hepatocyte Nuclear Factor-1A | ||
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