Design, Synthesis, and biological evaluation of a novel series of thiazole derivatives based on pyrazoline as anticancer agents | ||
| Egyptian Journal of Chemistry | ||
| Volume 65, Issue 132, December 2022, Pages 1241-1252 PDF (593.44 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2022.157866.6848 | ||
| Authors | ||
| Usama Fathy* 1; Mahmoud Nabil Mahmoud Yousif2; Eman M. Mohi El-Deen3; Eman Fayed4 | ||
| 1Applied Organic Chemistry depatment | ||
| 2Department of Photochemistry, National Research Centre, Cairo, Egypt | ||
| 3Therapeutic Chemistry Department, National Research Centre, Cairo, Egypt. | ||
| 44Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo 11754, Egypt | ||
| Abstract | ||
| This study deals with the design and synthesis of new pyrazoline-thiazole scaffold as promising anti-cancer agents, with the goal of building new compounds with combinations of various heterocyclic moieties. The pyrazoline-thiazole scaffold was synthesized via cyclization of the chalcone derivatives with thiosemicarbazide to afford the corresponding thioamide 5, which was the key precursor for synthesis of the compounds 7-15. Three cancer cell lines (MCF-7, HepG-2 and A549) were used to examine in vitro anticancer activities of the recently synthesized compounds. Three compounds 7c, 9c, and 11d were found to show the most promising anti-cancer activity against three cell lines. | ||
| Keywords | ||
| Chalcone; thioamide; pyrazoline; thiazole; haloketone; anti-cancer agent | ||
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